Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study

Pamela Minicozzi, Kaire Innos, Maria José Sánchez, A. Trama, Paul M. Walsh, Rafael Marcos-Gragera, Nadya Dimitrova, L. Botta, Otto Visser, S. Rossi, A. Tavilla, M. Sant, M. Hackl, N. Zielonke, E. Van Eycken, K. Henau, Z. Valerianova, N. Dimitrova, M. Sekerija, L. DušekM. Zvolský, M. Mägi, T. Aareleid, N. Malila, K. Seppä, A. M. Bouvier, J. Faivre, N. Bossard, Z. Uhry, G. Gatta, M. Sant, H. Amash, C. Amati, P. Baili, F. Berrino, S. Bonfarnuzzo, L. Botta, F. Di Salvo, R. Foschi, C. Margutti, E. Meneghini, Pamela Minicozzi, A. Trama, D. Serraino, L. Dal Maso, S. Rossi, R. A. Filiberti, M. Fusco, F. Falcini, S. Tognazzo, The EUROCARE-5 Working Group

Research output: Contribution to journalArticle

Abstract

Background Cancer registries (CRs) are fundamental for estimating cancer burden, evaluating screening and monitoring health service performance. Stage at diagnosis—an essential information item collected by CRs—has been made available, for the first time, by CRs participating in EUROCARE-5. We analysed the quality of this information and estimated stage-specific survival across Europe for CRs with good data quality. Data and methods Sixty-two CRs sent stage (as TNM, condensed TNM or extent of disease) for 15 cancers diagnosed in 2000–2007. We assessed the quality, partly by comparing stage according to the three systems. We also developed procedures to reconstruct stage (categories: local, regional, metastatic and unknown) using information from all three systems, thus minimising the amount of missing information. Results Moderate-to-excellent stage concordance was found for practically all 24 CRs, for which it was possible to compare at least two staging systems. However, since stage was often incorrectly assigned, and information on the presence/absence of metastases was often lacking, data on only 7/15 cancers from 34/62 CRs (15 countries) were of sufficient quality for further analysis. Cases diagnosed ≥70 years had more advanced (or lacking) stage– and worse stage-specific survival than those <70 years. Conclusions Many European CRs collect and record reasonably accurate stage information. Others have difficulties. Both the completeness of primary data and the accuracy of stage coding need to be improved in order for CRs to fulfil their expanding roles in cancer control. We propose our stage reconstruction/checking procedures as a means of fully exploiting the stage information provided by EUROCARE CRs. More advanced (or lacking) stage at diagnosis plus poorer stage-specific survival in the elderly are worrying.

Original languageEnglish
Pages (from-to)335-353
Number of pages19
JournalEuropean Journal of Cancer
Volume84
DOIs
Publication statusPublished - Oct 1 2017

Keywords

  • Cancer registries
  • Data quality
  • Stage at diagnosis
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Minicozzi, P., Innos, K., Sánchez, M. J., Trama, A., Walsh, P. M., Marcos-Gragera, R., Dimitrova, N., Botta, L., Visser, O., Rossi, S., Tavilla, A., Sant, M., Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., ... The EUROCARE-5 Working Group (2017). Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study. European Journal of Cancer, 84, 335-353. https://doi.org/10.1016/j.ejca.2017.07.015