Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study

P. Minicozzi, K. Innos, M.-J. Sánchez, A. Trama, P.M. Walsh, R. Marcos-Gragera, N. Dimitrova, L. Botta, O. Visser, S. Rossi, A. Tavilla, EUROCARE-5 Working Group, R. De Angelis, M. Caldora, S. Francisci, A. Knijn, S. Mallone, D. Pierannunzio, M. Santaquilani, Eugenio CarraniP. Roazzi

Research output: Contribution to journalArticle

Abstract

Background Cancer registries (CRs) are fundamental for estimating cancer burden, evaluating screening and monitoring health service performance. Stage at diagnosis—an essential information item collected by CRs—has been made available, for the first time, by CRs participating in EUROCARE-5. We analysed the quality of this information and estimated stage-specific survival across Europe for CRs with good data quality. Data and methods Sixty-two CRs sent stage (as TNM, condensed TNM or extent of disease) for 15 cancers diagnosed in 2000–2007. We assessed the quality, partly by comparing stage according to the three systems. We also developed procedures to reconstruct stage (categories: local, regional, metastatic and unknown) using information from all three systems, thus minimising the amount of missing information. Results Moderate-to-excellent stage concordance was found for practically all 24 CRs, for which it was possible to compare at least two staging systems. However, since stage was often incorrectly assigned, and information on the presence/absence of metastases was often lacking, data on only 7/15 cancers from 34/62 CRs (15 countries) were of sufficient quality for further analysis. Cases diagnosed ≥70 years had more advanced (or lacking) stage– and worse stage-specific survival than those
Original languageEnglish
Pages (from-to)335-353
Number of pages19
JournalEuropean Journal of Cancer
Volume84
DOIs
Publication statusPublished - 2017

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Keywords

  • Cancer registries
  • Data quality
  • Stage at diagnosis
  • Survival
  • Article
  • bladder cancer
  • breast cancer
  • cancer diagnosis
  • cancer localization
  • cancer patient
  • cancer registry
  • cancer staging
  • cancer survival
  • colon cancer
  • comparative study
  • controlled study
  • human
  • kidney cancer
  • lung cancer
  • major clinical study
  • malignant neoplasm
  • melanoma
  • ovary cancer
  • priority journal
  • prostate cancer
  • rectum cancer
  • stomach cancer
  • testis cancer
  • thyroid cancer
  • uterine cervix cancer
  • uterus cancer
  • vagina cancer
  • clinical trial
  • epidemiology
  • Europe
  • female
  • male
  • measurement accuracy
  • metastasis
  • mortality
  • multicenter study
  • Neoplasms
  • pathology
  • predictive value
  • register
  • reproducibility
  • survival analysis
  • Data Accuracy
  • Female
  • Humans
  • Male
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Predictive Value of Tests
  • Registries
  • Reproducibility of Results
  • Survival Analysis

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