Quality control in the endoplasmic reticulum protein factory

Roberto Sitia; Ineke Braakman

doi:10.1038/nature02262

Quality control in the endoplasmic reticulum protein factory

Roberto Sitia, Ineke Braakman

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.

Original language	English
Pages (from-to)	891-894
Number of pages	4
Journal	Nature
Volume	426
Issue number	6968
DOIs	https://doi.org/10.1038/nature02262
Publication status	Published - Dec 18 2003

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abstract = "The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.",

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Quality control in the endoplasmic reticulum protein factory

Abstract

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