Quality control in the endoplasmic reticulum protein factory

Roberto Sitia, Ineke Braakman

Research output: Contribution to journalArticle

Abstract

The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.

Original languageEnglish
Pages (from-to)891-894
Number of pages4
JournalNature
Volume426
Issue number6968
DOIs
Publication statusPublished - Dec 18 2003

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