Quality control of 99Mo/99Tcm generators: Results of a survey of the radiopharmacy working group of the Italian Association of Nuclear Medicine (AIMN)

M. Marengo; C. Aprile; C. Bagnara; C. Bolzati; C. Bonada; G. Candini; R. Casati; S. Civollani; F. R. Colombo; G. Compagnone; F. Del Dottore; E. Di Guglielmo; P. P. Ferretti; S. Lazzari; C. Minoia; D. Pancaldi; A. Ronchi; G. Sanità Di Toppi; R. Saponaro; T. Torregiani; L. Uccelli; F. Vecchi; A. Piffanelli

Quality control of ⁹⁹Mo/⁹⁹Tc^m generators: Results of a survey of the radiopharmacy working group of the Italian Association of Nuclear Medicine (AIMN)

M. Marengo, C. Aprile, C. Bagnara, C. Bolzati, C. Bonada, G. Candini, R. Casati, S. Civollani, F. R. Colombo, G. Compagnone, F. Del Dottore, E. Di Guglielmo, P. P. Ferretti, S. Lazzari, C. Minoia, D. Pancaldi, A. Ronchi, G. Sanità Di Toppi, R. Saponaro, T. TorregianiL. Uccelli, F. Vecchi, A. Piffanelli

Research output: Contribution to journal › Article › peer-review

Abstract

A multicentre survey of the quality control of ⁹⁹Tc^m generators has been completed: 245 generators from seven different commercial sources were tested over a period of 2 years. The results indicate that the mean pH of the eluates was 5.8 ± 0.6; the aluminium contents were typically <10 ppm; the radiochemical purity was 99.8 ± 0.4% and the median ⁹⁹Mo content was 3.8 x 10^-4 percent. The elution profiles gave a volume of 1.9 ml to obtain 50% of the total eluted activity and of 4.9ml to obtain 95%. Other radionuclide impurities and heavy metal breakthrough were evaluated by graphite furnace absorption spectrometry and inductively coupled plasma mass spectrometry. National guidelines for the standardization of radiopharmacy procedures are currently being compiled.

Original language	English
Pages (from-to)	1077-1084
Number of pages	8
Journal	Nuclear Medicine Communications
Volume	20
Issue number	11
Publication status	Published - 1999

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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Marengo, M., Aprile, C., Bagnara, C., Bolzati, C., Bonada, C., Candini, G., Casati, R., Civollani, S., Colombo, F. R., Compagnone, G., Del Dottore, F., Di Guglielmo, E., Ferretti, P. P., Lazzari, S., Minoia, C., Pancaldi, D., Ronchi, A., Sanità Di Toppi, G., Saponaro, R., ... Piffanelli, A. (1999). Quality control of ⁹⁹Mo/⁹⁹Tc^m generators: Results of a survey of the radiopharmacy working group of the Italian Association of Nuclear Medicine (AIMN). Nuclear Medicine Communications, 20(11), 1077-1084.

Quality control of ⁹⁹Mo/⁹⁹Tc^m generators : Results of a survey of the radiopharmacy working group of the Italian Association of Nuclear Medicine (AIMN). / Marengo, M.; Aprile, C.; Bagnara, C.; Bolzati, C.; Bonada, C.; Candini, G.; Casati, R.; Civollani, S.; Colombo, F. R.; Compagnone, G.; Del Dottore, F.; Di Guglielmo, E.; Ferretti, P. P.; Lazzari, S.; Minoia, C.; Pancaldi, D.; Ronchi, A.; Sanità Di Toppi, G.; Saponaro, R.; Torregiani, T.; Uccelli, L.; Vecchi, F.; Piffanelli, A.

In: Nuclear Medicine Communications, Vol. 20, No. 11, 1999, p. 1077-1084.

Research output: Contribution to journal › Article › peer-review

Marengo, M, Aprile, C, Bagnara, C, Bolzati, C, Bonada, C, Candini, G, Casati, R, Civollani, S, Colombo, FR, Compagnone, G, Del Dottore, F, Di Guglielmo, E, Ferretti, PP, Lazzari, S, Minoia, C, Pancaldi, D, Ronchi, A, Sanità Di Toppi, G, Saponaro, R, Torregiani, T, Uccelli, L, Vecchi, F & Piffanelli, A 1999, 'Quality control of ⁹⁹Mo/⁹⁹Tc^m generators: Results of a survey of the radiopharmacy working group of the Italian Association of Nuclear Medicine (AIMN)', Nuclear Medicine Communications, vol. 20, no. 11, pp. 1077-1084.

Marengo, M. ; Aprile, C. ; Bagnara, C. ; Bolzati, C. ; Bonada, C. ; Candini, G. ; Casati, R. ; Civollani, S. ; Colombo, F. R. ; Compagnone, G. ; Del Dottore, F. ; Di Guglielmo, E. ; Ferretti, P. P. ; Lazzari, S. ; Minoia, C. ; Pancaldi, D. ; Ronchi, A. ; Sanità Di Toppi, G. ; Saponaro, R. ; Torregiani, T. ; Uccelli, L. ; Vecchi, F. ; Piffanelli, A. / Quality control of ⁹⁹Mo/⁹⁹Tc^m generators : Results of a survey of the radiopharmacy working group of the Italian Association of Nuclear Medicine (AIMN). In: Nuclear Medicine Communications. 1999 ; Vol. 20, No. 11. pp. 1077-1084.

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abstract = "A multicentre survey of the quality control of 99Tcm generators has been completed: 245 generators from seven different commercial sources were tested over a period of 2 years. The results indicate that the mean pH of the eluates was 5.8 ± 0.6; the aluminium contents were typically <10 ppm; the radiochemical purity was 99.8 ± 0.4% and the median 99Mo content was 3.8 x 10-4 percent. The elution profiles gave a volume of 1.9 ml to obtain 50% of the total eluted activity and of 4.9ml to obtain 95%. Other radionuclide impurities and heavy metal breakthrough were evaluated by graphite furnace absorption spectrometry and inductively coupled plasma mass spectrometry. National guidelines for the standardization of radiopharmacy procedures are currently being compiled.",

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AU - Bagnara, C.

AU - Bolzati, C.

AU - Bonada, C.

AU - Candini, G.

AU - Casati, R.

AU - Civollani, S.

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AU - Del Dottore, F.

AU - Di Guglielmo, E.

AU - Ferretti, P. P.

AU - Lazzari, S.

AU - Minoia, C.

AU - Pancaldi, D.

AU - Ronchi, A.

AU - Sanità Di Toppi, G.

AU - Saponaro, R.

AU - Torregiani, T.

AU - Uccelli, L.

AU - Vecchi, F.

AU - Piffanelli, A.

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