Quality of harvest and role of cell dose in unrelated bone marrow transplantation: An Italian bone marrow donor registry-gruppo Italiano trapianto di midollo osseo study

Franca Fagioli, Paola Quarello, Simona Pollichieni, Teresa Lamparelli, Massimo Berger, Fabio Benedetti, Veronica Barat, Renato Marciano, Alessandro Rambaldi, Andrea Bacigalupo, Nicoletta Sacchi

Research output: Contribution to journalArticle

Abstract

In this study, we investigated the factors affecting cell dose harvest and the role of cell dose on outcome. We analysed data from a cohort of 703 patients who underwent unrelated bone marrow transplantation facilitated by IBMDR in GITMO centers between 2002 and 2008. The median-infused cell doses is 3.7 × 108/kg, the correlation between the nucleated cells requested from transplant centers and those harvested by collection centers was adequate. A harvested/requested cells ratio lower than 0.5 was observed only in 3% of harvests. A volume of harvested marrow higher than the median value of 1270 ml was related to a significant lower infused cell dose (χ2: 44.4; P <0.001). No patient-or donor-related variables significantly influenced the cell dose except for the recipient younger age (χ2: 95.7; P <0.001) and non-malignant diseases (χ2: 33.8; P <0.001). The cell dose resulted an independent predictor factor for a better outcome in patients affected by nonmalignant disease (P = 0.05) while early disease malignant patients receiving a lower cell dose showed a higher risk of relapse (P = 0.05).

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalHematology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Cell dose
  • Harvest
  • Relapse
  • Unrelated bone marrow transplantation

ASJC Scopus subject areas

  • Hematology

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    Fagioli, F., Quarello, P., Pollichieni, S., Lamparelli, T., Berger, M., Benedetti, F., Barat, V., Marciano, R., Rambaldi, A., Bacigalupo, A., & Sacchi, N. (2014). Quality of harvest and role of cell dose in unrelated bone marrow transplantation: An Italian bone marrow donor registry-gruppo Italiano trapianto di midollo osseo study. Hematology, 19(1), 1-9. https://doi.org/10.1179/1607845413Y.0000000086