Quality of life and length of survival in advanced cancer patients on home parenteral nutrition

F. Bozzetti, Luca Cozzaglio, E. Biganzoli, G. Chiavenna, M. De Cicco, D. Donati, G. Gilli, S. Percolla, L. Pironi

Research output: Contribution to journalArticlepeer-review


Background: The use of home parenteral nutrition (HPN) in patients with advanced cancer is controversial because survival is usually short and there are no data regarding the quality of life (QoL). Methods: Sixty-nine advanced cancer patients enrolled in a program of HPN in six different Italian centers were prospectively studied as regards nutritional status (body weight, serum albumin, serum transferrin and total lymphocyte count), length of survival and QoL through the Rotterdam Symptom Checklist questionnaire. These variables were collected at the start of HPN and then at monthly intervals. All these patients were severely malnourished, almost aphagic and beyond any possibility of cure. Results: Nutritional indices maintained stable until death. Median survival was 4 months (range 1-14) and about one-third of patients survived more than 7 months. QoL parameters remained stable till 2-3 months before death. Conclusions: HPN may benefit a limited percentage of patients who may survive longer than the time allowed by a condition of starvation and depletion. Provided that these patients survive longer than 3 months, there is some evidence that QoL remains stable for some months and acceptable for the patients.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalClinical Nutrition
Issue number4
Publication statusPublished - 2002


  • HPN
  • Incurable cancer patients
  • Nutritional support
  • Quality of life

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)
  • Medicine (miscellaneous)


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