Quality of life and motor impairment in ALS: Italian validation of ALSAQ

A. Palmieri, G. Sorarú, L. Lombardi, C. D'Ascenzo, L. Baggio, M. Ermani, E. Pegoraro, C. Angelini

Research output: Contribution to journalArticlepeer-review


Objectives: To evaluate the validity and reliability of the amyotrophic lateral sclerosis assessment questionnaire (ALSAQ) in an Italian cohort of ALS patients and to further characterize the relationship between motor impairment and quality of life (QoL) in ALS. Methods: Seventy-six patients completed the Italian version of ALSAQ-40 and ALSAQ-5. To verify test- retest reliability, 30 patients were revaluated after 3 months. The medical outcome study short form 36 (MOS SF-36) questionnaire and revised ALS functional rating scale (ALSFR-R) scale were used to assess Italian ALSAQ-40 construct validity. The limb muscles' Medical Research Council (MRC) score and forced vital capacity (FVC) were used to measure the degree of motor impairment. Results: The Italian ALSAQ-40 showed a very good internal consistency (all subscales Cronbach's alpha>0.86) and a good construct validity as shown by the patterns of correlation between the subscales and SF-36 (resp. ALSFRS-R) scores. ALSAQ-5 showed a positive correlation with the corresponding ALS patient total score and subscale scores of the ALSAQ-40 (Spearman's correlation coefficient>0.73). The emotional functioning subscale did not correlate with any motor impairment measures. Discussion: Italian ALSAQ-40 and ALSAQ-5 psychometric properties are reliable and similar to those showed by the original English version. We observed emotional aspects to be distinct from physical involvement.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalNeurological Research
Issue number1
Publication statusPublished - Feb 2010


  • ALS
  • ALSAQ-40
  • ALSAQ-5
  • Emotional functioning
  • Motor impairment
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Quality of life and motor impairment in ALS: Italian validation of ALSAQ'. Together they form a unique fingerprint.

Cite this