Quality of life and sexual, bladder, and intestinal dysfunctions after class III nerve-sparing and class II radical hysterectomies; A questionnaire-based study

Antonino Ditto, Fabio Martinelli, Claudia Borreani, Shigeki Kusamura, Francesco Hanozet, Cinzia Brunelli, Gabriela Rossi, Eugenio Solima, Rosanna Fontanelli, Flavia Zanaboni, Barbara Grijuela, Francesco Raspagliesi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: To compare quality of life and bladder, intestinal, and sexual dysfunctions in 2 groups of patients undergoing different types of radical hysterectomies (RHs). Methods: Patients with cervical cancer who underwent RH have been enrolled in a questionnaire-based study. Quality of life (QoL) and bladder, intestinal, and sexual dysfunctions were evaluated with the Functional Assessment of Cancer TherapyVCervix (FACT-Cx). Patients were grouped according to the type of RH: group 1, class II RH and group 2, class III nerve-sparing RH (NSRH).Results: Of 157 women included in the study, 127 filled out the questionnaire. Overall, QoL score assessed with the FACT questionnaire did not differ significantly between the 2 groups. The FACT subscales assessing physical, functional, emotional, and social wellbeing did not differ significantly between the 2 groups, whereas the FACT-Cx subscales assessing disease-related symptoms in group 2 patients showed a significantly worse score (72 vs 66; P = 0.03). Evaluating singularly the 15 items of the Cx subscales assessing disease-related symptoms, we did not find any significant difference between the 2 groups, but only Cx1 ("I am bothered by discharge or bleeding from my vagina") was significantly worse in group 2 patients. At univariate analysis, we found that SRH and adjuvant radiotherapy (RT) impact negatively on the FACT-Cx subscales regarding pelvic visceral function. However, at multivariate analysis, only adjuvant RT impact negatively. Conclusions: Patients submitted to class III NSRH did not present worse QoL and pelvic visceral dysfunctions when compared with class II RH. The RT seems to be a factorimpacting negatively on bladder and sexual function.

Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume19
Issue number5
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Oculomotor Nerve
Hysterectomy
Urinary Bladder
Quality of Life
Adjuvant Radiotherapy
Neoplasms
Vagina
Uterine Cervical Neoplasms
Surveys and Questionnaires
Radiotherapy
Multivariate Analysis
Hemorrhage

Keywords

  • Cervical cancer
  • Nerve-sparing technique
  • Quality of life
  • Questionnaire
  • Radical hysterectomy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)

Cite this

Quality of life and sexual, bladder, and intestinal dysfunctions after class III nerve-sparing and class II radical hysterectomies; A questionnaire-based study. / Ditto, Antonino; Martinelli, Fabio; Borreani, Claudia; Kusamura, Shigeki; Hanozet, Francesco; Brunelli, Cinzia; Rossi, Gabriela; Solima, Eugenio; Fontanelli, Rosanna; Zanaboni, Flavia; Grijuela, Barbara; Raspagliesi, Francesco.

In: International Journal of Gynecological Cancer, Vol. 19, No. 5, 07.2009, p. 953-957.

Research output: Contribution to journalArticle

Ditto, Antonino ; Martinelli, Fabio ; Borreani, Claudia ; Kusamura, Shigeki ; Hanozet, Francesco ; Brunelli, Cinzia ; Rossi, Gabriela ; Solima, Eugenio ; Fontanelli, Rosanna ; Zanaboni, Flavia ; Grijuela, Barbara ; Raspagliesi, Francesco. / Quality of life and sexual, bladder, and intestinal dysfunctions after class III nerve-sparing and class II radical hysterectomies; A questionnaire-based study. In: International Journal of Gynecological Cancer. 2009 ; Vol. 19, No. 5. pp. 953-957.
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abstract = "Background: To compare quality of life and bladder, intestinal, and sexual dysfunctions in 2 groups of patients undergoing different types of radical hysterectomies (RHs). Methods: Patients with cervical cancer who underwent RH have been enrolled in a questionnaire-based study. Quality of life (QoL) and bladder, intestinal, and sexual dysfunctions were evaluated with the Functional Assessment of Cancer TherapyVCervix (FACT-Cx). Patients were grouped according to the type of RH: group 1, class II RH and group 2, class III nerve-sparing RH (NSRH).Results: Of 157 women included in the study, 127 filled out the questionnaire. Overall, QoL score assessed with the FACT questionnaire did not differ significantly between the 2 groups. The FACT subscales assessing physical, functional, emotional, and social wellbeing did not differ significantly between the 2 groups, whereas the FACT-Cx subscales assessing disease-related symptoms in group 2 patients showed a significantly worse score (72 vs 66; P = 0.03). Evaluating singularly the 15 items of the Cx subscales assessing disease-related symptoms, we did not find any significant difference between the 2 groups, but only Cx1 ({"}I am bothered by discharge or bleeding from my vagina{"}) was significantly worse in group 2 patients. At univariate analysis, we found that SRH and adjuvant radiotherapy (RT) impact negatively on the FACT-Cx subscales regarding pelvic visceral function. However, at multivariate analysis, only adjuvant RT impact negatively. Conclusions: Patients submitted to class III NSRH did not present worse QoL and pelvic visceral dysfunctions when compared with class II RH. The RT seems to be a factorimpacting negatively on bladder and sexual function.",
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T1 - Quality of life and sexual, bladder, and intestinal dysfunctions after class III nerve-sparing and class II radical hysterectomies; A questionnaire-based study

AU - Ditto, Antonino

AU - Martinelli, Fabio

AU - Borreani, Claudia

AU - Kusamura, Shigeki

AU - Hanozet, Francesco

AU - Brunelli, Cinzia

AU - Rossi, Gabriela

AU - Solima, Eugenio

AU - Fontanelli, Rosanna

AU - Zanaboni, Flavia

AU - Grijuela, Barbara

AU - Raspagliesi, Francesco

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N2 - Background: To compare quality of life and bladder, intestinal, and sexual dysfunctions in 2 groups of patients undergoing different types of radical hysterectomies (RHs). Methods: Patients with cervical cancer who underwent RH have been enrolled in a questionnaire-based study. Quality of life (QoL) and bladder, intestinal, and sexual dysfunctions were evaluated with the Functional Assessment of Cancer TherapyVCervix (FACT-Cx). Patients were grouped according to the type of RH: group 1, class II RH and group 2, class III nerve-sparing RH (NSRH).Results: Of 157 women included in the study, 127 filled out the questionnaire. Overall, QoL score assessed with the FACT questionnaire did not differ significantly between the 2 groups. The FACT subscales assessing physical, functional, emotional, and social wellbeing did not differ significantly between the 2 groups, whereas the FACT-Cx subscales assessing disease-related symptoms in group 2 patients showed a significantly worse score (72 vs 66; P = 0.03). Evaluating singularly the 15 items of the Cx subscales assessing disease-related symptoms, we did not find any significant difference between the 2 groups, but only Cx1 ("I am bothered by discharge or bleeding from my vagina") was significantly worse in group 2 patients. At univariate analysis, we found that SRH and adjuvant radiotherapy (RT) impact negatively on the FACT-Cx subscales regarding pelvic visceral function. However, at multivariate analysis, only adjuvant RT impact negatively. Conclusions: Patients submitted to class III NSRH did not present worse QoL and pelvic visceral dysfunctions when compared with class II RH. The RT seems to be a factorimpacting negatively on bladder and sexual function.

AB - Background: To compare quality of life and bladder, intestinal, and sexual dysfunctions in 2 groups of patients undergoing different types of radical hysterectomies (RHs). Methods: Patients with cervical cancer who underwent RH have been enrolled in a questionnaire-based study. Quality of life (QoL) and bladder, intestinal, and sexual dysfunctions were evaluated with the Functional Assessment of Cancer TherapyVCervix (FACT-Cx). Patients were grouped according to the type of RH: group 1, class II RH and group 2, class III nerve-sparing RH (NSRH).Results: Of 157 women included in the study, 127 filled out the questionnaire. Overall, QoL score assessed with the FACT questionnaire did not differ significantly between the 2 groups. The FACT subscales assessing physical, functional, emotional, and social wellbeing did not differ significantly between the 2 groups, whereas the FACT-Cx subscales assessing disease-related symptoms in group 2 patients showed a significantly worse score (72 vs 66; P = 0.03). Evaluating singularly the 15 items of the Cx subscales assessing disease-related symptoms, we did not find any significant difference between the 2 groups, but only Cx1 ("I am bothered by discharge or bleeding from my vagina") was significantly worse in group 2 patients. At univariate analysis, we found that SRH and adjuvant radiotherapy (RT) impact negatively on the FACT-Cx subscales regarding pelvic visceral function. However, at multivariate analysis, only adjuvant RT impact negatively. Conclusions: Patients submitted to class III NSRH did not present worse QoL and pelvic visceral dysfunctions when compared with class II RH. The RT seems to be a factorimpacting negatively on bladder and sexual function.

KW - Cervical cancer

KW - Nerve-sparing technique

KW - Quality of life

KW - Questionnaire

KW - Radical hysterectomy

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