Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: A case series

Gabriella MacChia; Alessio G. Morganti; Savino Cilla; Edy Ippolito; Mariangela Massaccesi; Vincenzo Picardi; Gian Carlo Mattiucci; Pierluigi Bonomo; Rosa Tambaro; Fabio Pacelli; Angelo Piermattei; Marco De Spirito; Vincenzo Valentini; Numa Cellini; Francesco Deodato

doi:10.3109/07357907.2011.640649

Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: A case series

Gabriella MacChia, Alessio G. Morganti, Savino Cilla, Edy Ippolito, Mariangela Massaccesi, Vincenzo Picardi, Gian Carlo Mattiucci, Pierluigi Bonomo, Rosa Tambaro, Fabio Pacelli, Angelo Piermattei, Marco De Spirito, Vincenzo Valentini, Numa Cellini, Francesco Deodato

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article

Abstract

Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients' quality of life.

Original language	English
Pages (from-to)	149-155
Number of pages	7
Journal	Cancer Investigation
Volume	30
Issue number	2
DOIs	https://doi.org/10.3109/07357907.2011.640649
Publication status	Published - Feb 2012

Keywords

ESRT
Pancreatic tumors
Quality of life
Stereotactic radiotherapy

ASJC Scopus subject areas

Cancer Research
Oncology

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MacChia, G., Morganti, A. G., Cilla, S., Ippolito, E., Massaccesi, M., Picardi, V., Mattiucci, G. C., Bonomo, P., Tambaro, R., Pacelli, F., Piermattei, A., De Spirito, M., Valentini, V., Cellini, N., & Deodato, F. (2012). Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: A case series. Cancer Investigation, 30(2), 149-155. https://doi.org/10.3109/07357907.2011.640649

Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors : A case series. / MacChia, Gabriella; Morganti, Alessio G.; Cilla, Savino; Ippolito, Edy; Massaccesi, Mariangela; Picardi, Vincenzo; Mattiucci, Gian Carlo; Bonomo, Pierluigi; Tambaro, Rosa; Pacelli, Fabio; Piermattei, Angelo; De Spirito, Marco; Valentini, Vincenzo; Cellini, Numa; Deodato, Francesco.

In: Cancer Investigation, Vol. 30, No. 2, 02.2012, p. 149-155.

Research output: Contribution to journal › Article

MacChia, G, Morganti, AG, Cilla, S, Ippolito, E, Massaccesi, M, Picardi, V, Mattiucci, GC, Bonomo, P, Tambaro, R, Pacelli, F, Piermattei, A, De Spirito, M, Valentini, V, Cellini, N & Deodato, F 2012, 'Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: A case series', Cancer Investigation, vol. 30, no. 2, pp. 149-155. https://doi.org/10.3109/07357907.2011.640649

MacChia, Gabriella ; Morganti, Alessio G. ; Cilla, Savino ; Ippolito, Edy ; Massaccesi, Mariangela ; Picardi, Vincenzo ; Mattiucci, Gian Carlo ; Bonomo, Pierluigi ; Tambaro, Rosa ; Pacelli, Fabio ; Piermattei, Angelo ; De Spirito, Marco ; Valentini, Vincenzo ; Cellini, Numa ; Deodato, Francesco. / Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors : A case series. In: Cancer Investigation. 2012 ; Vol. 30, No. 2. pp. 149-155.

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