Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: A case series

Gabriella MacChia, Alessio G. Morganti, Savino Cilla, Edy Ippolito, Mariangela Massaccesi, Vincenzo Picardi, Gian Carlo Mattiucci, Pierluigi Bonomo, Rosa Tambaro, Fabio Pacelli, Angelo Piermattei, Marco De Spirito, Vincenzo Valentini, Numa Cellini, Francesco Deodato

Research output: Contribution to journalArticlepeer-review


Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients' quality of life.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalCancer Investigation
Issue number2
Publication statusPublished - Feb 2012


  • ESRT
  • Pancreatic tumors
  • Quality of life
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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