TY - JOUR
T1 - Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors
T2 - A case series
AU - MacChia, Gabriella
AU - Morganti, Alessio G.
AU - Cilla, Savino
AU - Ippolito, Edy
AU - Massaccesi, Mariangela
AU - Picardi, Vincenzo
AU - Mattiucci, Gian Carlo
AU - Bonomo, Pierluigi
AU - Tambaro, Rosa
AU - Pacelli, Fabio
AU - Piermattei, Angelo
AU - De Spirito, Marco
AU - Valentini, Vincenzo
AU - Cellini, Numa
AU - Deodato, Francesco
PY - 2012/2
Y1 - 2012/2
N2 - Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients' quality of life.
AB - Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients' quality of life.
KW - ESRT
KW - Pancreatic tumors
KW - Quality of life
KW - Stereotactic radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84856093701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856093701&partnerID=8YFLogxK
U2 - 10.3109/07357907.2011.640649
DO - 10.3109/07357907.2011.640649
M3 - Article
C2 - 22250589
AN - SCOPUS:84856093701
VL - 30
SP - 149
EP - 155
JO - Cancer Investigation
JF - Cancer Investigation
SN - 0735-7907
IS - 2
ER -