Quality of Life Assessment With Orthotopic Ileal Neobladder Reconstruction After Radical Cystectomy: Results From a Prospective Italian Multicenter Observational Study

Ciro Imbimbo, Vincenzo Mirone, Salvatore Siracusano, Mauro Niero, Maria A ngela Cerruto, Cristina Lonardi, Walter Artibani, Pierfrancesco Bassi, Massimo Iafrate, Marco Racioppi, Renato Talamini, Stefano Ciciliato, Laura Toffoli, Francesco Visalli, Davide Massidda, Carolina D'Elia, Giovanni Cacciamani, Davide De Marchi, Tommaso Silvestri, Massimiliano CretaEmanuele Belgrano, Paolo Verze

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess health-related quality of life (HRQoL) parameters in patients who received radical cystectomy (RC) with ileal orthotopic neobladder (IONB) reconstruction and to identify clinic-pathologic predictors of HRQoL.

PATIENTS AND METHODS: From January 2010 to December 2013, a multicenter, retrospective on 174 RC-IONB patients was carried out. All patients completed the following questionnaires: the European Organization for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB-Patient Reported Outcome (IONB-PRO). Univariate and multivariate analyses were computed to identify clinic-pathologic predictors of HRQoL.

RESULTS: Median age was 66 years (range, 31-83), and 91.4% of patients were men. Median follow-up period was 37 months (range, 3-247). The EORTC QLQ-C30 revealed that age >65 years, absence of urinary incontinence, and absence of peripheral vascular disease were independent predictors of deteriorated body image. A follow-up > 36 months and the presence of urinary incontinence were independent predictors of worsened urinary symptoms, whereas the absence of urinary incontinence was an independent predictor of a worsened body image according to EORTC QLQ-BLM30 results. A follow-up >36 months and the absence of urinary incontinence were independent predictors of better functioning in terms of relational life, emotional life, and fatigue as revealed by the IONB-PRO.

CONCLUSION: Age, presence of urinary incontinence, length of follow-up, and comorbidity status may influence postoperative HRQoL and should all be taken into account when counseling RC-IONB patients.

Original languageEnglish
Pages (from-to)974-979
Number of pages6
JournalUrology
Volume86
Issue number5
DOIs
Publication statusPublished - Nov 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Urology

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    Imbimbo, C., Mirone, V., Siracusano, S., Niero, M., Cerruto, M. A. N., Lonardi, C., Artibani, W., Bassi, P., Iafrate, M., Racioppi, M., Talamini, R., Ciciliato, S., Toffoli, L., Visalli, F., Massidda, D., D'Elia, C., Cacciamani, G., De Marchi, D., Silvestri, T., ... Verze, P. (2015). Quality of Life Assessment With Orthotopic Ileal Neobladder Reconstruction After Radical Cystectomy: Results From a Prospective Italian Multicenter Observational Study. Urology, 86(5), 974-979. https://doi.org/10.1016/j.urology.2015.06.058