TY - JOUR
T1 - Quality of Life Assessment With Orthotopic Ileal Neobladder Reconstruction After Radical Cystectomy
T2 - Results From a Prospective Italian Multicenter Observational Study
AU - Imbimbo, Ciro
AU - Mirone, Vincenzo
AU - Siracusano, Salvatore
AU - Niero, Mauro
AU - Cerruto, Maria A ngela
AU - Lonardi, Cristina
AU - Artibani, Walter
AU - Bassi, Pierfrancesco
AU - Iafrate, Massimo
AU - Racioppi, Marco
AU - Talamini, Renato
AU - Ciciliato, Stefano
AU - Toffoli, Laura
AU - Visalli, Francesco
AU - Massidda, Davide
AU - D'Elia, Carolina
AU - Cacciamani, Giovanni
AU - De Marchi, Davide
AU - Silvestri, Tommaso
AU - Creta, Massimiliano
AU - Belgrano, Emanuele
AU - Verze, Paolo
PY - 2015/11/1
Y1 - 2015/11/1
N2 - OBJECTIVE: To assess health-related quality of life (HRQoL) parameters in patients who received radical cystectomy (RC) with ileal orthotopic neobladder (IONB) reconstruction and to identify clinic-pathologic predictors of HRQoL.PATIENTS AND METHODS: From January 2010 to December 2013, a multicenter, retrospective on 174 RC-IONB patients was carried out. All patients completed the following questionnaires: the European Organization for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB-Patient Reported Outcome (IONB-PRO). Univariate and multivariate analyses were computed to identify clinic-pathologic predictors of HRQoL.RESULTS: Median age was 66 years (range, 31-83), and 91.4% of patients were men. Median follow-up period was 37 months (range, 3-247). The EORTC QLQ-C30 revealed that age >65 years, absence of urinary incontinence, and absence of peripheral vascular disease were independent predictors of deteriorated body image. A follow-up > 36 months and the presence of urinary incontinence were independent predictors of worsened urinary symptoms, whereas the absence of urinary incontinence was an independent predictor of a worsened body image according to EORTC QLQ-BLM30 results. A follow-up >36 months and the absence of urinary incontinence were independent predictors of better functioning in terms of relational life, emotional life, and fatigue as revealed by the IONB-PRO.CONCLUSION: Age, presence of urinary incontinence, length of follow-up, and comorbidity status may influence postoperative HRQoL and should all be taken into account when counseling RC-IONB patients.
AB - OBJECTIVE: To assess health-related quality of life (HRQoL) parameters in patients who received radical cystectomy (RC) with ileal orthotopic neobladder (IONB) reconstruction and to identify clinic-pathologic predictors of HRQoL.PATIENTS AND METHODS: From January 2010 to December 2013, a multicenter, retrospective on 174 RC-IONB patients was carried out. All patients completed the following questionnaires: the European Organization for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB-Patient Reported Outcome (IONB-PRO). Univariate and multivariate analyses were computed to identify clinic-pathologic predictors of HRQoL.RESULTS: Median age was 66 years (range, 31-83), and 91.4% of patients were men. Median follow-up period was 37 months (range, 3-247). The EORTC QLQ-C30 revealed that age >65 years, absence of urinary incontinence, and absence of peripheral vascular disease were independent predictors of deteriorated body image. A follow-up > 36 months and the presence of urinary incontinence were independent predictors of worsened urinary symptoms, whereas the absence of urinary incontinence was an independent predictor of a worsened body image according to EORTC QLQ-BLM30 results. A follow-up >36 months and the absence of urinary incontinence were independent predictors of better functioning in terms of relational life, emotional life, and fatigue as revealed by the IONB-PRO.CONCLUSION: Age, presence of urinary incontinence, length of follow-up, and comorbidity status may influence postoperative HRQoL and should all be taken into account when counseling RC-IONB patients.
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U2 - 10.1016/j.urology.2015.06.058
DO - 10.1016/j.urology.2015.06.058
M3 - Article
C2 - 26291562
VL - 86
SP - 974
EP - 979
JO - Urology
JF - Urology
SN - 0090-4295
IS - 5
ER -