Quality of life following urinary diversion

Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors

Salvatore Siracusano, Carolina D'Elia, Maria Angela Cerruto, Mauro Gacci, Stefano Ciciliato, Alchiede Simonato, Antonio Porcaro, Vincenzo De Marco, Renato Talamini, Laura Toffoli, Omar Saleh, Sergio Serni, Francesco Visalli, Mauro Niero, Cristina Lonardi, Ciro Imbimbo, Paolo Verze, Vincenzo Mirone, Marco Racioppi, Massimo Iafrate & 4 others Giovanni Cacciamani, Davide De Marchi, Pierfrancesco Bassi, Walter Artibani

Research output: Contribution to journalArticle

Abstract

Introduction: Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. Materials and methods: We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres. Patients had no evidence of tumour recurrence and were actively followed up. Validated Italian versions of the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder-cancer-specific (QLQ-BLM30) questionnaires were used to evaluate HRQOL. Results: Patients in the IONB group were significantly younger than those in the IC group (median age: 67 and 73 years, respectively, p = 0.02). Barring that, the two groups did not present statistically significant differences in median length of follow-up (43 vs 54 months), pathological stage, grading of the neoplasm, or adjuvant chemo - or radiotherapy. No significant differences in QOL were found between the groups, with the exception of financial difficulties, affecting IONB patients significantly more than IC patients (mean score on a scale of 0–100: 33.3 ± 29.5 vs 18.4 ± 19.3, respectively; p = 0.05). Conclusion: Financial difficulties was the only HRQOL item to differ between the two UD groups.

Original languageEnglish
JournalEuropean Journal of Surgical Oncology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Urinary Diversion
Urinary Bladder Neoplasms
Multicenter Studies
Survivors
Quality of Life
Cystectomy
Neoplasm Grading
Urinary Bladder
Radiotherapy
Age Groups
Recurrence
Neoplasms

Keywords

  • Bladder cancer
  • Ileal conduit
  • Orthotopic neobladder
  • Quality of life
  • Radical cystectomy
  • Women

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Quality of life following urinary diversion : Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors. / Siracusano, Salvatore; D'Elia, Carolina; Cerruto, Maria Angela; Gacci, Mauro; Ciciliato, Stefano; Simonato, Alchiede; Porcaro, Antonio; De Marco, Vincenzo; Talamini, Renato; Toffoli, Laura; Saleh, Omar; Serni, Sergio; Visalli, Francesco; Niero, Mauro; Lonardi, Cristina; Imbimbo, Ciro; Verze, Paolo; Mirone, Vincenzo; Racioppi, Marco; Iafrate, Massimo; Cacciamani, Giovanni; De Marchi, Davide; Bassi, Pierfrancesco; Artibani, Walter.

In: European Journal of Surgical Oncology, 01.01.2018.

Research output: Contribution to journalArticle

Siracusano, S, D'Elia, C, Cerruto, MA, Gacci, M, Ciciliato, S, Simonato, A, Porcaro, A, De Marco, V, Talamini, R, Toffoli, L, Saleh, O, Serni, S, Visalli, F, Niero, M, Lonardi, C, Imbimbo, C, Verze, P, Mirone, V, Racioppi, M, Iafrate, M, Cacciamani, G, De Marchi, D, Bassi, P & Artibani, W 2018, 'Quality of life following urinary diversion: Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors', European Journal of Surgical Oncology. https://doi.org/10.1016/j.ejso.2018.10.061
Siracusano, Salvatore ; D'Elia, Carolina ; Cerruto, Maria Angela ; Gacci, Mauro ; Ciciliato, Stefano ; Simonato, Alchiede ; Porcaro, Antonio ; De Marco, Vincenzo ; Talamini, Renato ; Toffoli, Laura ; Saleh, Omar ; Serni, Sergio ; Visalli, Francesco ; Niero, Mauro ; Lonardi, Cristina ; Imbimbo, Ciro ; Verze, Paolo ; Mirone, Vincenzo ; Racioppi, Marco ; Iafrate, Massimo ; Cacciamani, Giovanni ; De Marchi, Davide ; Bassi, Pierfrancesco ; Artibani, Walter. / Quality of life following urinary diversion : Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors. In: European Journal of Surgical Oncology. 2018.
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abstract = "Introduction: Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. Materials and methods: We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres. Patients had no evidence of tumour recurrence and were actively followed up. Validated Italian versions of the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder-cancer-specific (QLQ-BLM30) questionnaires were used to evaluate HRQOL. Results: Patients in the IONB group were significantly younger than those in the IC group (median age: 67 and 73 years, respectively, p = 0.02). Barring that, the two groups did not present statistically significant differences in median length of follow-up (43 vs 54 months), pathological stage, grading of the neoplasm, or adjuvant chemo - or radiotherapy. No significant differences in QOL were found between the groups, with the exception of financial difficulties, affecting IONB patients significantly more than IC patients (mean score on a scale of 0–100: 33.3 ± 29.5 vs 18.4 ± 19.3, respectively; p = 0.05). Conclusion: Financial difficulties was the only HRQOL item to differ between the two UD groups.",
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T1 - Quality of life following urinary diversion

T2 - Orthotopic ileal neobladder versus ileal conduit. A multicentre study among long-term, female bladder cancer survivors

AU - Siracusano, Salvatore

AU - D'Elia, Carolina

AU - Cerruto, Maria Angela

AU - Gacci, Mauro

AU - Ciciliato, Stefano

AU - Simonato, Alchiede

AU - Porcaro, Antonio

AU - De Marco, Vincenzo

AU - Talamini, Renato

AU - Toffoli, Laura

AU - Saleh, Omar

AU - Serni, Sergio

AU - Visalli, Francesco

AU - Niero, Mauro

AU - Lonardi, Cristina

AU - Imbimbo, Ciro

AU - Verze, Paolo

AU - Mirone, Vincenzo

AU - Racioppi, Marco

AU - Iafrate, Massimo

AU - Cacciamani, Giovanni

AU - De Marchi, Davide

AU - Bassi, Pierfrancesco

AU - Artibani, Walter

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. Materials and methods: We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres. Patients had no evidence of tumour recurrence and were actively followed up. Validated Italian versions of the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder-cancer-specific (QLQ-BLM30) questionnaires were used to evaluate HRQOL. Results: Patients in the IONB group were significantly younger than those in the IC group (median age: 67 and 73 years, respectively, p = 0.02). Barring that, the two groups did not present statistically significant differences in median length of follow-up (43 vs 54 months), pathological stage, grading of the neoplasm, or adjuvant chemo - or radiotherapy. No significant differences in QOL were found between the groups, with the exception of financial difficulties, affecting IONB patients significantly more than IC patients (mean score on a scale of 0–100: 33.3 ± 29.5 vs 18.4 ± 19.3, respectively; p = 0.05). Conclusion: Financial difficulties was the only HRQOL item to differ between the two UD groups.

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KW - Bladder cancer

KW - Ileal conduit

KW - Orthotopic neobladder

KW - Quality of life

KW - Radical cystectomy

KW - Women

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