Quality of life in coeliac patients: Italian validation of a coeliac questionnaire

Alessandra Marchese, Catherine Klersy, Federico Biagi, Davide Balduzzi, Paola I. Bianchi, Lucia Trotta, Claudia Vattiato, Alessandra Zilli, Johannes Rademacher, Alida Andrealli, Marco Astegiano, Ilaria Michelini, Wienfried Häuser, Gino R. Corazza

Research output: Contribution to journalArticlepeer-review


Background: Coeliac disease (CD) is a chronic condition requiring a gluten-free diet, which is a very demanding diet to maintain on a life-long basis. For this reason it is a condition that can have serious repercussions on the quality of life (QOL). Therefore the need to elaborate a questionnaire on QOL specifically for patients with CD (CDQ): its original language is German, and the translation/validation process represents a considerable challenge involving not only a translation into Italian but also an adaptation to the country's specific cultural differences. Methods: The questionnaire has been translated according to a "German→Italian→Italian→ German" algorithm with reconciliation of the differences. Scores for CDQ are computed overall and over four areas of four items each: emotion, gastrointestinal symptoms, gastrointestinal worries, social problems. Results: CDQ was administered to 171 coeliacs (F 132, mean age 38 yrs ± 14). Completeness was optimal. Item internal consistency was satisfied for 100% and 97% of patients for the specific and generic part, respectively. Cronbach's α coefficient was 0.7 for all scales. The general CDQ was higher in patients reporting subjective well-being (discriminant validity). Conclusions: The Italian translation of CDQ sounds natural, is easy to understand and reduces possible cultural biases to a minimum. A field test gave results comparable to the original validation, supporting the use of CDQ in cross-national surveys.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalEuropean Journal of Internal Medicine
Issue number1
Publication statusPublished - Jan 2013


  • Celiac disease
  • Gliadin
  • Quality of life assessment
  • Questionnaires

ASJC Scopus subject areas

  • Internal Medicine

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