Quality of life in malignant brain tumor patients following surgery. radiotherapy and chemotherapy

A. R. Giovagnoli, A. Pozzi, A. Silvani, O. Pelati, S. Mascheroni, A. Boiardi

Research output: Contribution to journalArticlepeer-review


Objective to evaluate quality of life (QL) in disease free malignant brain tumor patients Subjects 37 patients submitted to surgery and combined radiotherapy and chemotherapy according to histologie diagnosis, haematologic and physical criteria (Karnofsky Performance Status KPS- > 40) Mean disease duration was 24 months Methods Functional Living Index-Cancer (FLIC), Activities Daily Living (ADL), KPS. State-Trait Anxiety Inventory (STAI), SelfRating Depression Scale (SRDS). Raven Coloured Progressive Matrices (PM), Attentional Matrices (AM), Trail Making Test (TMT), Story Recall (SR) Results. Twenty patients showed FLIC scores (as global indices of QL) higher than 118 and KPS scores equal to or higher than 90 The minimum KPS score of 60 was found in six patients. No patients was demented FLIC scores significantly correlated with KPS, STAI. SRDS, PM, AM and TMT scores (p<01) Female patients showed higher FLIC scores than male patients Regression analisys revealed that the FLIC score was significantly associated with SRDS and AM scores, disease duration, sex, age, education and marital status did not show any relationship A separate regression analysis showed a significant association of the SRDS score with FLIC and TMT scores Conclusions Disease free malignant brain tumor patients may preserve work and fair psychosocial activities. QL appears to be mainly affected by mood slate and mental slowing. Depression may be related to cognitive disabilities and changes of daily life more then to the awareness of coping with a malignant disease.

Original languageEnglish
Pages (from-to)142
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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