Abstract
Dystonia is a disabling and disfiguring disorder that can often affect many aspects of patients' daily lives, and lower their self-esteem. To date, quality of life (QoL) has been assessed in dystonic patients using generic measures that do not address the specific problems of this diagnostic group. Recently, two disease-specific scales "The Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)" were validated for measuring QoL in craniocervical dystonia patients. No disease-specific scales for QoL for dystonic patients are currently available in Italian. The aim of our study was to produce and validate the Italian version of the CDIP-58 and CDQ-24. We obtained the Italian version of CDQ-24 and CDIP-58 with a back-translation design. Both scales were applied to a population of 94 craniocervical dystonia patients along with the Short Form 36 health-survey questionnaire (SF-36), both before and 4 weeks after botulinum toxin therapy. A group of 65 controls matched for sex, age and comorbidity underwent the SF-36. Internal consistency was satisfactory for all subscales. Both the CDIP-58 and CDQ-24 showed moderate to high correlations with similar items of the SF-36. Sensitivity to change was confirmed by highly significant improvements in all CDQ-24 subscales and by moderate improvements in three out of eight CDIP-58 subscales and total score. This is the first Italian study on QoL in dystonia patients. We validated the Italian version of two disease-specific questionnaires to evaluate QoL in craniocervical dystonia patients. These scales could be useful for both clinical practice and clinical trials.
| Original language | English |
|---|---|
| Pages (from-to) | 1053-1058 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 35 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- CDIP-58
- CDQ-24
- Craniocervical dystonia
- Quality of life
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
- Medicine(all)
Cite this
Quality of life in patients with craniocervical dystonia : Italian validation of the "Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)". / Fabbri, Margherita; Superbo, Maria; Defazio, Giovanni; Scaglione, Cesa Lorella Maria; Antelmi, Elena; Basini, Giacomo; Nassetti, Stefania; Pizza, Fabio; Plasmati, Rosaria; Liguori, Rocco.
In: Neurological Sciences, Vol. 35, No. 7, 2014, p. 1053-1058.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quality of life in patients with craniocervical dystonia
T2 - Italian validation of the "Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)"
AU - Fabbri, Margherita
AU - Superbo, Maria
AU - Defazio, Giovanni
AU - Scaglione, Cesa Lorella Maria
AU - Antelmi, Elena
AU - Basini, Giacomo
AU - Nassetti, Stefania
AU - Pizza, Fabio
AU - Plasmati, Rosaria
AU - Liguori, Rocco
PY - 2014
Y1 - 2014
N2 - Dystonia is a disabling and disfiguring disorder that can often affect many aspects of patients' daily lives, and lower their self-esteem. To date, quality of life (QoL) has been assessed in dystonic patients using generic measures that do not address the specific problems of this diagnostic group. Recently, two disease-specific scales "The Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)" were validated for measuring QoL in craniocervical dystonia patients. No disease-specific scales for QoL for dystonic patients are currently available in Italian. The aim of our study was to produce and validate the Italian version of the CDIP-58 and CDQ-24. We obtained the Italian version of CDQ-24 and CDIP-58 with a back-translation design. Both scales were applied to a population of 94 craniocervical dystonia patients along with the Short Form 36 health-survey questionnaire (SF-36), both before and 4 weeks after botulinum toxin therapy. A group of 65 controls matched for sex, age and comorbidity underwent the SF-36. Internal consistency was satisfactory for all subscales. Both the CDIP-58 and CDQ-24 showed moderate to high correlations with similar items of the SF-36. Sensitivity to change was confirmed by highly significant improvements in all CDQ-24 subscales and by moderate improvements in three out of eight CDIP-58 subscales and total score. This is the first Italian study on QoL in dystonia patients. We validated the Italian version of two disease-specific questionnaires to evaluate QoL in craniocervical dystonia patients. These scales could be useful for both clinical practice and clinical trials.
AB - Dystonia is a disabling and disfiguring disorder that can often affect many aspects of patients' daily lives, and lower their self-esteem. To date, quality of life (QoL) has been assessed in dystonic patients using generic measures that do not address the specific problems of this diagnostic group. Recently, two disease-specific scales "The Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)" were validated for measuring QoL in craniocervical dystonia patients. No disease-specific scales for QoL for dystonic patients are currently available in Italian. The aim of our study was to produce and validate the Italian version of the CDIP-58 and CDQ-24. We obtained the Italian version of CDQ-24 and CDIP-58 with a back-translation design. Both scales were applied to a population of 94 craniocervical dystonia patients along with the Short Form 36 health-survey questionnaire (SF-36), both before and 4 weeks after botulinum toxin therapy. A group of 65 controls matched for sex, age and comorbidity underwent the SF-36. Internal consistency was satisfactory for all subscales. Both the CDIP-58 and CDQ-24 showed moderate to high correlations with similar items of the SF-36. Sensitivity to change was confirmed by highly significant improvements in all CDQ-24 subscales and by moderate improvements in three out of eight CDIP-58 subscales and total score. This is the first Italian study on QoL in dystonia patients. We validated the Italian version of two disease-specific questionnaires to evaluate QoL in craniocervical dystonia patients. These scales could be useful for both clinical practice and clinical trials.
KW - CDIP-58
KW - CDQ-24
KW - Craniocervical dystonia
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=84903385387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903385387&partnerID=8YFLogxK
U2 - 10.1007/s10072-014-1642-7
DO - 10.1007/s10072-014-1642-7
M3 - Article
VL - 35
SP - 1053
EP - 1058
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 7
ER -