Quality of surgery and neoadjuvant combined therapy in the ISG-GEIS trial on soft tissue sarcomas of limbs and trunk wall

A. Gronchi, P. Verderio, A. De Paoli, A. Ferraro, O. Tendero, J. Majó, J. Martin, A. Comandone, G. Grignani, S. Pizzamiglio, V. Quagliuolo, P. Picci, S. Frustaci, A. P. Dei Tos, E. Palassini, S. Stacchiotti, S. Ferrari, M. Fiore, P. G. Casali

Research output: Contribution to journalArticlepeer-review


Background: To explore correlation between the quality of surgery and outcome in high-risk soft tissue sarcoma (STS) patients treated within a phase III randomized trial. Patients and Methods: In the trial, all patients received three cycles of preoperative chemotherapy (CT) with epirubicin 120 mg/m2 and ifosfamide 9 g/m2 and were randomly assigned to receive two further postoperative cycles. Radiotherapy (RT) could be delivered in the preoperative or postoperative setting. The association between surgical margins andoverall survival (OS) was studied in a univariate and multivariate fashion. Results: Two hundred and fifty-two patients completed the whole treatment and were operated conservatively. At a median follow-up of 60 months (IQR, 45-74 months), the 5-year OS was 0.73,even in patients with positive and negative margins. The 5-year cumulative incidence (CI) of local recurrence (LR) in patients with positive and negative microscopic margins was 0.17 (standard error, SE, 0.08) and 0.03 (SE, 0.01), respectively. In the subgroup of patients receiving combined preoperative CT-RT and with positive surgical margins, the CI of LR was 0. Conclusions: In this setting of high-risk STS treated by preoperative CT or CT-RT, the negative impact of positive margins on the outcome was limited. When close margins can be anticipated preoperative CT-RT may be a reasonable option to maximize the chance of cure.

Original languageEnglish
Article numbermds501
Pages (from-to)817-823
Number of pages7
JournalAnnals of Oncology
Issue number3
Publication statusPublished - Mar 2013


  • Chemotherapy
  • Local recurrence
  • Radiation therapy
  • Sarcoma
  • Surgical margins
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Hematology


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