QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL

Hugo Câmara-Costa, Kim Bull, Colin Kennedy, Andreas Wiener, Gabriele Calaminus, Anika Resch, Virginie Kieffer, Clemence Lalande, Geraldina Poggi, Katja Von Hoff, Jacques Grill, Francois Doz, Stefan Rutkowski, Maura Massimino, Rolf Dieter Kortmann, Birgitta Lannering, Georges Dellatolas, Mathilde Chevignard, Quality of Survival Working Group of the Brain Tumour Group SIOP Europ

Research output: Contribution to journalArticle

Abstract

Background. The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires
evaluating distinct domains of QoS tend to be strong. This pattern remains understudied.
Methods. In the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard-risk
medulloblastoma from 4 European countries. QoS questionnaires, including self-reports and/or parent reports of the Behavior Rating Inventory of Executive Function (BRIEF), the Health Utilities Index, the Strengths and Difficulties
Questionnaire, and the Pediatric Quality of Life Inventory, were completed for 151 survivors. Correlations among direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n = 86).
Results. Correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition Index (parent report) and working memory (r = .32) and between health status (self-report) and cognitive outcomes (r = .35–.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (r = .39–.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on 2 separate factors.
Conclusions. We hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions on the questionnaires, coupled with the relative absence of diseasespecific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.
Original languageEnglish
Pages (from-to)161-170
JournalNeuro-Oncology Practice
Volume4
Issue number3
Publication statusPublished - 2017

Fingerprint

Primitive Neuroectodermal Tumors
Medulloblastoma
Randomized Controlled Trials
Survival
Self Report
Executive Function
Short-Term Memory
Equipment and Supplies
Survivors
Surveys and Questionnaires
Principal Component Analysis
Health Status
Personality
Quality of Life
Clinical Trials
Pediatrics

Cite this

Câmara-Costa, H., Bull, K., Kennedy, C., Wiener, A., Calaminus, G., Resch, A., ... Quality of Survival Working Group of the Brain Tumour Group SIOP Europ (2017). QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL. Neuro-Oncology Practice, 4(3), 161-170.

QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL. / Câmara-Costa, Hugo; Bull, Kim; Kennedy, Colin; Wiener, Andreas; Calaminus, Gabriele; Resch, Anika; Kieffer, Virginie; Lalande, Clemence; Poggi, Geraldina; Von Hoff, Katja; Grill, Jacques; Doz, Francois; Rutkowski, Stefan; Massimino, Maura; Kortmann, Rolf Dieter; Lannering, Birgitta; Dellatolas, Georges; Chevignard, Mathilde; Quality of Survival Working Group of the Brain Tumour Group SIOP Europ.

In: Neuro-Oncology Practice, Vol. 4, No. 3, 2017, p. 161-170.

Research output: Contribution to journalArticle

Câmara-Costa, H, Bull, K, Kennedy, C, Wiener, A, Calaminus, G, Resch, A, Kieffer, V, Lalande, C, Poggi, G, Von Hoff, K, Grill, J, Doz, F, Rutkowski, S, Massimino, M, Kortmann, RD, Lannering, B, Dellatolas, G, Chevignard, M & Quality of Survival Working Group of the Brain Tumour Group SIOP Europ 2017, 'QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL', Neuro-Oncology Practice, vol. 4, no. 3, pp. 161-170.
Câmara-Costa, Hugo ; Bull, Kim ; Kennedy, Colin ; Wiener, Andreas ; Calaminus, Gabriele ; Resch, Anika ; Kieffer, Virginie ; Lalande, Clemence ; Poggi, Geraldina ; Von Hoff, Katja ; Grill, Jacques ; Doz, Francois ; Rutkowski, Stefan ; Massimino, Maura ; Kortmann, Rolf Dieter ; Lannering, Birgitta ; Dellatolas, Georges ; Chevignard, Mathilde ; Quality of Survival Working Group of the Brain Tumour Group SIOP Europ. / QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL. In: Neuro-Oncology Practice. 2017 ; Vol. 4, No. 3. pp. 161-170.
@article{76d59a01e5f74304a1d2d0411db75614,
title = "QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL",
abstract = "Background. The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnairesevaluating distinct domains of QoS tend to be strong. This pattern remains understudied.Methods. In the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard-riskmedulloblastoma from 4 European countries. QoS questionnaires, including self-reports and/or parent reports of the Behavior Rating Inventory of Executive Function (BRIEF), the Health Utilities Index, the Strengths and DifficultiesQuestionnaire, and the Pediatric Quality of Life Inventory, were completed for 151 survivors. Correlations among direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n = 86).Results. Correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition Index (parent report) and working memory (r = .32) and between health status (self-report) and cognitive outcomes (r = .35–.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (r = .39–.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on 2 separate factors.Conclusions. We hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions on the questionnaires, coupled with the relative absence of diseasespecific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.",
author = "Hugo C{\^a}mara-Costa and Kim Bull and Colin Kennedy and Andreas Wiener and Gabriele Calaminus and Anika Resch and Virginie Kieffer and Clemence Lalande and Geraldina Poggi and {Von Hoff}, Katja and Jacques Grill and Francois Doz and Stefan Rutkowski and Maura Massimino and Kortmann, {Rolf Dieter} and Birgitta Lannering and Georges Dellatolas and Mathilde Chevignard and {Quality of Survival Working Group of the Brain Tumour Group SIOP Europ}",
year = "2017",
language = "English",
volume = "4",
pages = "161--170",
journal = "Neuro-Oncology Practice",
issn = "2054-2577",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - QUALITY OF SURVIVAL AND COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL

AU - Câmara-Costa, Hugo

AU - Bull, Kim

AU - Kennedy, Colin

AU - Wiener, Andreas

AU - Calaminus, Gabriele

AU - Resch, Anika

AU - Kieffer, Virginie

AU - Lalande, Clemence

AU - Poggi, Geraldina

AU - Von Hoff, Katja

AU - Grill, Jacques

AU - Doz, Francois

AU - Rutkowski, Stefan

AU - Massimino, Maura

AU - Kortmann, Rolf Dieter

AU - Lannering, Birgitta

AU - Dellatolas, Georges

AU - Chevignard, Mathilde

AU - Quality of Survival Working Group of the Brain Tumour Group SIOP Europ

PY - 2017

Y1 - 2017

N2 - Background. The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnairesevaluating distinct domains of QoS tend to be strong. This pattern remains understudied.Methods. In the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard-riskmedulloblastoma from 4 European countries. QoS questionnaires, including self-reports and/or parent reports of the Behavior Rating Inventory of Executive Function (BRIEF), the Health Utilities Index, the Strengths and DifficultiesQuestionnaire, and the Pediatric Quality of Life Inventory, were completed for 151 survivors. Correlations among direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n = 86).Results. Correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition Index (parent report) and working memory (r = .32) and between health status (self-report) and cognitive outcomes (r = .35–.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (r = .39–.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on 2 separate factors.Conclusions. We hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions on the questionnaires, coupled with the relative absence of diseasespecific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.

AB - Background. The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnairesevaluating distinct domains of QoS tend to be strong. This pattern remains understudied.Methods. In the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard-riskmedulloblastoma from 4 European countries. QoS questionnaires, including self-reports and/or parent reports of the Behavior Rating Inventory of Executive Function (BRIEF), the Health Utilities Index, the Strengths and DifficultiesQuestionnaire, and the Pediatric Quality of Life Inventory, were completed for 151 survivors. Correlations among direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n = 86).Results. Correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition Index (parent report) and working memory (r = .32) and between health status (self-report) and cognitive outcomes (r = .35–.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (r = .39–.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on 2 separate factors.Conclusions. We hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions on the questionnaires, coupled with the relative absence of diseasespecific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.

M3 - Article

VL - 4

SP - 161

EP - 170

JO - Neuro-Oncology Practice

JF - Neuro-Oncology Practice

SN - 2054-2577

IS - 3

ER -