QuantiFERON TB Gold Plus for the diagnosis of tuberculosis: a systematic review and meta-analysis

Giovanni Sotgiu, Laura Saderi, Elisa Petruccioli, Stefano Aliberti, Andrea Piana, Linda Petrone, Delia Goletti

Research output: Contribution to journalArticlepeer-review


Estimated 2017 tuberculosis (TB) incidence is 10 million and mainly depends on the reservoir of individuals with latent TB infection (LTBI). Quantiferon-TB Gold in-Tube (QFT-GIT) is one of the tests used for LTBI detection. Since 2015 a new version, Quantiferon-TB Gold Plus (QFT-Plus) is available. Objectives: To perform a systematic review and meta-analysis to assess the diagnostic accuracy for TB of QFT-Plus compared to QFT-GIT. Methods: PubMed and Scopus were used to detect records related to predefined strings from 2015 to 2018. Full text articles dealing with the sensitivity and/or specificity of the QFT-Plus vs. QFT-GIT for active-TB and LTBI detection were analyzed. Scientific quality and risk of bias were assessed using QADAS-2. Results: We selected 15 articles. Studies were mainly observational and cross-sectional, performed in 8 countries. Sample size differed in the TB group (27 to 164) compared to LTBI group (29 to 1031). Pooled sensitivity of QFT-Plus for active-TB was 0.94 (0.91 and 0.95 for TB1 and TB2, respectively), whereas pooled specificity for healthy status was 0.96. Pooled sensitivity and specificity for LTBI was 0.91 and 0.95, respectively. Conclusions: We show that QFT-Plus is more sensitive compared to QFT-GIT for detecting M. tuberculosis infection, mainly due to TB2 responses.

Original languageEnglish
Pages (from-to)1-22
Number of pages22
JournalJournal of Infection
Publication statusAccepted/In press - Aug 29 2019


  • Meta-analysis
  • QuantiFERON TB Gold Plus
  • TB, LTBI

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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