Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging

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Abstract

BACKGROUND AND PURPOSE: Increasing evidence exists that cerebral gray matter (GM) from patients with multiple sclerosis (MS) is not spared. This study was performed to quantify in vivo the extent of cerebral GM pathologic abnormality in patients with relapsing-remitting (RR), secondary progressive (SP), and primary progressive MS, by using diffusion tensor (DT) MR imaging. METHODS: Dual-echo and DT MR imaging of the brain were performed in 102 patients with MS and 30 healthy volunteers. After GM segmentation using a technique based on diffusion anisotropy thresholding, average diffusivity (D̄) histograms of the cerebral GM were produced for all participants. RESULTS: All D̄ histogram-derived metrics of the GM were significantly different between control volunteers and the whole MS population. No significant difference was found for any of the D̄ histogram-derived metrics between control volunteers and patients with RRMS, whereas significant differences were found for D̄ and D̄ histogram peak location between control volunteers and patients with PPMS. All the D̄ histogram-derived metrics differed significantly between patients with RRMS and patients with SPMS. Patients with SPMS also had significantly lower D̄ than did patients with PPMS. All D̄ histogram-derived metrics of the GM were strongly correlated with the T2 lesion volume. CONCLUSIONS: This study confirms the presence of brain GM changes in patients with MS. It also shows that the extent of such changes is greater during the progressive forms of the disease.

Original languageEnglish
Pages (from-to)985-988
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume23
Issue number6
Publication statusPublished - 2002

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Diffusion Tensor Imaging
Multiple Sclerosis
Phenotype
Brain
Volunteers
Gray Matter
Chronic Progressive Multiple Sclerosis
Anisotropy
Healthy Volunteers

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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title = "Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging",
abstract = "BACKGROUND AND PURPOSE: Increasing evidence exists that cerebral gray matter (GM) from patients with multiple sclerosis (MS) is not spared. This study was performed to quantify in vivo the extent of cerebral GM pathologic abnormality in patients with relapsing-remitting (RR), secondary progressive (SP), and primary progressive MS, by using diffusion tensor (DT) MR imaging. METHODS: Dual-echo and DT MR imaging of the brain were performed in 102 patients with MS and 30 healthy volunteers. After GM segmentation using a technique based on diffusion anisotropy thresholding, average diffusivity (D̄) histograms of the cerebral GM were produced for all participants. RESULTS: All D̄ histogram-derived metrics of the GM were significantly different between control volunteers and the whole MS population. No significant difference was found for any of the D̄ histogram-derived metrics between control volunteers and patients with RRMS, whereas significant differences were found for D̄ and D̄ histogram peak location between control volunteers and patients with PPMS. All the D̄ histogram-derived metrics differed significantly between patients with RRMS and patients with SPMS. Patients with SPMS also had significantly lower D̄ than did patients with PPMS. All D̄ histogram-derived metrics of the GM were strongly correlated with the T2 lesion volume. CONCLUSIONS: This study confirms the presence of brain GM changes in patients with MS. It also shows that the extent of such changes is greater during the progressive forms of the disease.",
author = "Marco Bozzali and Mara Cercignani and Sormani, {Maria Pia} and Giancarlo Comi and Massimo Filippi",
year = "2002",
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T1 - Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging

AU - Bozzali, Marco

AU - Cercignani, Mara

AU - Sormani, Maria Pia

AU - Comi, Giancarlo

AU - Filippi, Massimo

PY - 2002

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N2 - BACKGROUND AND PURPOSE: Increasing evidence exists that cerebral gray matter (GM) from patients with multiple sclerosis (MS) is not spared. This study was performed to quantify in vivo the extent of cerebral GM pathologic abnormality in patients with relapsing-remitting (RR), secondary progressive (SP), and primary progressive MS, by using diffusion tensor (DT) MR imaging. METHODS: Dual-echo and DT MR imaging of the brain were performed in 102 patients with MS and 30 healthy volunteers. After GM segmentation using a technique based on diffusion anisotropy thresholding, average diffusivity (D̄) histograms of the cerebral GM were produced for all participants. RESULTS: All D̄ histogram-derived metrics of the GM were significantly different between control volunteers and the whole MS population. No significant difference was found for any of the D̄ histogram-derived metrics between control volunteers and patients with RRMS, whereas significant differences were found for D̄ and D̄ histogram peak location between control volunteers and patients with PPMS. All the D̄ histogram-derived metrics differed significantly between patients with RRMS and patients with SPMS. Patients with SPMS also had significantly lower D̄ than did patients with PPMS. All D̄ histogram-derived metrics of the GM were strongly correlated with the T2 lesion volume. CONCLUSIONS: This study confirms the presence of brain GM changes in patients with MS. It also shows that the extent of such changes is greater during the progressive forms of the disease.

AB - BACKGROUND AND PURPOSE: Increasing evidence exists that cerebral gray matter (GM) from patients with multiple sclerosis (MS) is not spared. This study was performed to quantify in vivo the extent of cerebral GM pathologic abnormality in patients with relapsing-remitting (RR), secondary progressive (SP), and primary progressive MS, by using diffusion tensor (DT) MR imaging. METHODS: Dual-echo and DT MR imaging of the brain were performed in 102 patients with MS and 30 healthy volunteers. After GM segmentation using a technique based on diffusion anisotropy thresholding, average diffusivity (D̄) histograms of the cerebral GM were produced for all participants. RESULTS: All D̄ histogram-derived metrics of the GM were significantly different between control volunteers and the whole MS population. No significant difference was found for any of the D̄ histogram-derived metrics between control volunteers and patients with RRMS, whereas significant differences were found for D̄ and D̄ histogram peak location between control volunteers and patients with PPMS. All the D̄ histogram-derived metrics differed significantly between patients with RRMS and patients with SPMS. Patients with SPMS also had significantly lower D̄ than did patients with PPMS. All D̄ histogram-derived metrics of the GM were strongly correlated with the T2 lesion volume. CONCLUSIONS: This study confirms the presence of brain GM changes in patients with MS. It also shows that the extent of such changes is greater during the progressive forms of the disease.

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