Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease

Sang-Eun Lee; Ji Min Sung; Asim Rizvi; Fay Y Lin; Amit Kumar; Martin Hadamitzky; Yong-Jin Kim; Edoardo Conte; Daniele Andreini; Gianluca Pontone; Matthew J Budoff; Ilan Gottlieb; Byoung Kwon Lee; Eun Ju Chun; Filippo Cademartiri; Erica Maffei; Hugo Marques; Jonathon A Leipsic; Sanghoon Shin; Jung Hyun Choi; Kavitha Chinnaiyan; Gilbert Raff; Renu Virmani; Habib Samady; Peter H Stone; Daniel S Berman; Jagat Narula; Leslee J Shaw; Jeroen J Bax; James K Min; Hyuk-Jae Chang

doi:10.1161/CIRCIMAGING.117.007562

Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease

Sang-Eun Lee, Ji Min Sung, Asim Rizvi, Fay Y Lin, Amit Kumar, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Jonathon A Leipsic, Sanghoon Shin, Jung Hyun ChoiKavitha Chinnaiyan, Gilbert Raff, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min, Hyuk-Jae Chang

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression.METHODS AND RESULTS: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (△PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of △PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P

Original language	English
Pages (from-to)	e007562
Journal	Circulation: Cardiovascular Imaging
Volume	11
Issue number	7
DOIs	https://doi.org/10.1161/CIRCIMAGING.117.007562
Publication status	Published - Jul 2018

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Lee, S-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., ... Chang, H-J. (2018). Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease. Circulation: Cardiovascular Imaging, 11(7), e007562. https://doi.org/10.1161/CIRCIMAGING.117.007562

Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease. / Lee, Sang-Eun; Sung, Ji Min; Rizvi, Asim; Lin, Fay Y; Kumar, Amit; Hadamitzky, Martin; Kim, Yong-Jin; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Lee, Byoung Kwon; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Leipsic, Jonathon A; Shin, Sanghoon; Hyun Choi, Jung; Chinnaiyan, Kavitha; Raff, Gilbert; Virmani, Renu; Samady, Habib; Stone, Peter H; Berman, Daniel S; Narula, Jagat; Shaw, Leslee J; Bax, Jeroen J; Min, James K; Chang, Hyuk-Jae.

In: Circulation: Cardiovascular Imaging, Vol. 11, No. 7, 07.2018, p. e007562.

Research output: Contribution to journal › Article › peer-review

Lee, S-E, Sung, JM, Rizvi, A, Lin, FY, Kumar, A, Hadamitzky, M, Kim, Y-J, Conte, E, Andreini, D, Pontone, G, Budoff, MJ, Gottlieb, I, Lee, BK, Chun, EJ, Cademartiri, F, Maffei, E, Marques, H, Leipsic, JA, Shin, S, Hyun Choi, J, Chinnaiyan, K, Raff, G, Virmani, R, Samady, H, Stone, PH, Berman, DS, Narula, J, Shaw, LJ, Bax, JJ, Min, JK & Chang, H-J 2018, 'Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease', Circulation: Cardiovascular Imaging, vol. 11, no. 7, pp. e007562. https://doi.org/10.1161/CIRCIMAGING.117.007562

Lee, Sang-Eun ; Sung, Ji Min ; Rizvi, Asim ; Lin, Fay Y ; Kumar, Amit ; Hadamitzky, Martin ; Kim, Yong-Jin ; Conte, Edoardo ; Andreini, Daniele ; Pontone, Gianluca ; Budoff, Matthew J ; Gottlieb, Ilan ; Lee, Byoung Kwon ; Chun, Eun Ju ; Cademartiri, Filippo ; Maffei, Erica ; Marques, Hugo ; Leipsic, Jonathon A ; Shin, Sanghoon ; Hyun Choi, Jung ; Chinnaiyan, Kavitha ; Raff, Gilbert ; Virmani, Renu ; Samady, Habib ; Stone, Peter H ; Berman, Daniel S ; Narula, Jagat ; Shaw, Leslee J ; Bax, Jeroen J ; Min, James K ; Chang, Hyuk-Jae. / Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease. In: Circulation: Cardiovascular Imaging. 2018 ; Vol. 11, No. 7. pp. e007562.

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abstract = "BACKGROUND: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression.METHODS AND RESULTS: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (△PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of △PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P",

author = "Sang-Eun Lee and Sung, {Ji Min} and Asim Rizvi and Lin, {Fay Y} and Amit Kumar and Martin Hadamitzky and Yong-Jin Kim and Edoardo Conte and Daniele Andreini and Gianluca Pontone and Budoff, {Matthew J} and Ilan Gottlieb and Lee, {Byoung Kwon} and Chun, {Eun Ju} and Filippo Cademartiri and Erica Maffei and Hugo Marques and Leipsic, {Jonathon A} and Sanghoon Shin and {Hyun Choi}, Jung and Kavitha Chinnaiyan and Gilbert Raff and Renu Virmani and Habib Samady and Stone, {Peter H} and Berman, {Daniel S} and Jagat Narula and Shaw, {Leslee J} and Bax, {Jeroen J} and Min, {James K} and Hyuk-Jae Chang",

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AU - Lee, Sang-Eun

AU - Sung, Ji Min

AU - Rizvi, Asim

AU - Lin, Fay Y

AU - Kumar, Amit

AU - Hadamitzky, Martin

AU - Kim, Yong-Jin

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Pontone, Gianluca

AU - Budoff, Matthew J

AU - Gottlieb, Ilan

AU - Lee, Byoung Kwon

AU - Chun, Eun Ju

AU - Cademartiri, Filippo

AU - Maffei, Erica

AU - Marques, Hugo

AU - Leipsic, Jonathon A

AU - Shin, Sanghoon

AU - Hyun Choi, Jung

AU - Chinnaiyan, Kavitha

AU - Raff, Gilbert

AU - Virmani, Renu

AU - Samady, Habib

AU - Stone, Peter H

AU - Berman, Daniel S

AU - Narula, Jagat

AU - Shaw, Leslee J

AU - Bax, Jeroen J

AU - Min, James K

AU - Chang, Hyuk-Jae

PY - 2018/7

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N2 - BACKGROUND: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression.METHODS AND RESULTS: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (△PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of △PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P

AB - BACKGROUND: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression.METHODS AND RESULTS: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (△PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of △PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P

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