TY - JOUR
T1 - Quantification of fatty tissue mass by magnetic resonance imaging in arrhythmogenic right ventricular dysplasia
AU - Fattori, Rossella
AU - Tricoci, Pierluigi
AU - Russo, Vincenzo
AU - Lovato, Luigi
AU - Bacchi-Reggiani, Letizia
AU - Gavelli, Giampaolo
AU - Branzi, Angelo
AU - Boriani, Giuseppe
PY - 2005/3
Y1 - 2005/3
N2 - Quantification of Fatty Tissue Mass. Introduction: Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder in which the pathological substrate is a fatty or fibro-fatty replacement of the right ventricular (RV) myocardium. Methods and Results: Magnetic resonance imaging (MRI) studies were performed in 10 patients with arrhythmogenic right ventricular dysplasia and in 24 matched controls in order to assess right ventricular epicardial/intramyocardial fatty tissue mass, RV myocardial mass, and RV functional parameters. Functional abnormalities were found in all ARVD cases. Patients with ARVD showed increased fatty tissue compared to controls (8.2 ± 4 g vs. 2.0 ± 1.0 g; P = 0.001), whereas no significant differences were found in RV myocardial mass (29.5 ± 9.2 g vs. 23.2 ± 6.7 g; P = NS). A correlation coefficient between 0.87 and 0.97 was found for repeated measurements. Conclusion: Quantification of fatty tissue with MRI is feasible and constitutes an objective method for differentiating normal from pathological conditions. This approach may lead to a complete diagnostic assessment of ARVD with the potential application for monitoring the evolution of the disease.
AB - Quantification of Fatty Tissue Mass. Introduction: Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder in which the pathological substrate is a fatty or fibro-fatty replacement of the right ventricular (RV) myocardium. Methods and Results: Magnetic resonance imaging (MRI) studies were performed in 10 patients with arrhythmogenic right ventricular dysplasia and in 24 matched controls in order to assess right ventricular epicardial/intramyocardial fatty tissue mass, RV myocardial mass, and RV functional parameters. Functional abnormalities were found in all ARVD cases. Patients with ARVD showed increased fatty tissue compared to controls (8.2 ± 4 g vs. 2.0 ± 1.0 g; P = 0.001), whereas no significant differences were found in RV myocardial mass (29.5 ± 9.2 g vs. 23.2 ± 6.7 g; P = NS). A correlation coefficient between 0.87 and 0.97 was found for repeated measurements. Conclusion: Quantification of fatty tissue with MRI is feasible and constitutes an objective method for differentiating normal from pathological conditions. This approach may lead to a complete diagnostic assessment of ARVD with the potential application for monitoring the evolution of the disease.
KW - ARVD
KW - Fatty/adipose tissue
KW - MRI
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U2 - 10.1046/j.1540-8167.2004.40498.x
DO - 10.1046/j.1540-8167.2004.40498.x
M3 - Article
C2 - 15817082
AN - SCOPUS:15544374907
VL - 16
SP - 256
EP - 261
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
SN - 1045-3873
IS - 3
ER -