Quantification of fatty tissue mass by magnetic resonance imaging in arrhythmogenic right ventricular dysplasia

Rossella Fattori, Pierluigi Tricoci, Vincenzo Russo, Luigi Lovato, Letizia Bacchi-Reggiani, Giampaolo Gavelli, Angelo Branzi, Giuseppe Boriani

Research output: Contribution to journalArticlepeer-review

Abstract

Quantification of Fatty Tissue Mass. Introduction: Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder in which the pathological substrate is a fatty or fibro-fatty replacement of the right ventricular (RV) myocardium. Methods and Results: Magnetic resonance imaging (MRI) studies were performed in 10 patients with arrhythmogenic right ventricular dysplasia and in 24 matched controls in order to assess right ventricular epicardial/intramyocardial fatty tissue mass, RV myocardial mass, and RV functional parameters. Functional abnormalities were found in all ARVD cases. Patients with ARVD showed increased fatty tissue compared to controls (8.2 ± 4 g vs. 2.0 ± 1.0 g; P = 0.001), whereas no significant differences were found in RV myocardial mass (29.5 ± 9.2 g vs. 23.2 ± 6.7 g; P = NS). A correlation coefficient between 0.87 and 0.97 was found for repeated measurements. Conclusion: Quantification of fatty tissue with MRI is feasible and constitutes an objective method for differentiating normal from pathological conditions. This approach may lead to a complete diagnostic assessment of ARVD with the potential application for monitoring the evolution of the disease.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • ARVD
  • Fatty/adipose tissue
  • MRI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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