Quantification of manual thrombus removal in patients with acute coronary syndromes: A study exploiting serial frequency domain-optical coherence tomography

Fabrizio Imola, Maria Teresa Mallus, Vito Ramazzotti, Alessandro Manzoli, Luca Di Vito, Michele Occhipinti, Alberto Cremonesi, Eloisa Arbustini, Francesco Prati, Mario Albertucci

Research output: Contribution to journalArticle

Abstract

Aims: Thrombus aspiration is useful in improving myocardial reperfusion in comparison to conventional percutaneous coronary intervention in patients with acute myocardial infarction. Nonetheless, assessment of thrombus aspiration efficacy is lacking. Aim of this study was to quantify by frequency domain optical coherence tomography (OCT) the amount of thrombus removal in patients with acute coronary syndromes undergoing manual thrombus aspiration, correlating it with the actual size of the retrieved material. Methods: Twenty-five consecutive patients with acute coronary syndrome were enrolled. OCT assessment of thrombotic lesions was performed before and after thrombus aspiration and repeated after stent deployment. OCT thrombus assessment was based on an established scoring technique. The aspirated material was analyzed by histology, and its planimetry was correlated with OCTderived thrombus removal. Results: The percentage of thrombus removal [(prethrombus aspiration minus post-thrombus aspiration)/(prethrombus aspirationT100)] was 48.9; the delta measurement of the removed thrombus calculated by OCT correlated well with the planimetry-measured aspirated material (r=0.56, P

Original languageEnglish
Pages (from-to)204-212
Number of pages9
JournalJournal of Cardiovascular Medicine
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • Acute coronary syndrome
  • Myocardial infarction
  • Optical coherence tomography
  • Thrombus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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