Quantification of Multicontrast Vascular MR Images with NLSnake, an Active Contour Model: In Vitro Validation and In Vivo Evaluation

Catherine Desbleds Mansard, Emmanuelle P. Canet Soulas, Alfred Anwander, Linda Chaabane, Bruno Neyran, Jean Michel Serfaty, Isabelle E. Magnin, Philippe C. Douek, Maciej Orkisz

Research output: Contribution to journalArticle

Abstract

Vessel-wall measurements from multicontrast MRI provide information on plaque structure and evolution. This requires the extraction of numerous contours. In this work a contour-extraction method is proposed that uses an active contour model (NLSnake) adapted for a wide range of MR vascular images. This new method employs length normalization for the purpose of deformation computation and offers the advantages of simplified parameter tuning, fast convergence, and minimal user interaction. The model can be initialized far from the boundaries of the region to be segmented, even by only one pixel. The accuracy and reproducibility of NLSnake endoluminal contours were assessed on vascular phantom MR angiography (MRA) and high-resolution in vitro MR images of rabbit aorta. An in vivo evaluation was performed on rabbit and clinical data for both internal and external vessel-wall contours. In phantoms with 95% stenoses, NLSnake measured 94.3% ± 3.8%, and the accuracy was even better for milder stenoses. In the images of rabbit aorta, variability between NLSnake and experts was less than interobserver variability, while the maximum intravariability of NLSnake was equal to 1.25%. In conclusion, the NLSnake technique successfully quantified the vessel lumen in multicontrast MR images using constant parameters.

Original languageEnglish
Pages (from-to)370-379
Number of pages10
JournalMagnetic Resonance in Medicine
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2004

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Blood Vessels
Rabbits
Aorta
Pathologic Constriction
Observer Variation
Angiography
In Vitro Techniques

Keywords

  • Active contour model
  • Atherosclerosis
  • Image processing
  • MR vascular images
  • Quantification

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Mansard, C. D., Canet Soulas, E. P., Anwander, A., Chaabane, L., Neyran, B., Serfaty, J. M., ... Orkisz, M. (2004). Quantification of Multicontrast Vascular MR Images with NLSnake, an Active Contour Model: In Vitro Validation and In Vivo Evaluation. Magnetic Resonance in Medicine, 51(2), 370-379. https://doi.org/10.1002/mrm.10722

Quantification of Multicontrast Vascular MR Images with NLSnake, an Active Contour Model : In Vitro Validation and In Vivo Evaluation. / Mansard, Catherine Desbleds; Canet Soulas, Emmanuelle P.; Anwander, Alfred; Chaabane, Linda; Neyran, Bruno; Serfaty, Jean Michel; Magnin, Isabelle E.; Douek, Philippe C.; Orkisz, Maciej.

In: Magnetic Resonance in Medicine, Vol. 51, No. 2, 02.2004, p. 370-379.

Research output: Contribution to journalArticle

Mansard, CD, Canet Soulas, EP, Anwander, A, Chaabane, L, Neyran, B, Serfaty, JM, Magnin, IE, Douek, PC & Orkisz, M 2004, 'Quantification of Multicontrast Vascular MR Images with NLSnake, an Active Contour Model: In Vitro Validation and In Vivo Evaluation', Magnetic Resonance in Medicine, vol. 51, no. 2, pp. 370-379. https://doi.org/10.1002/mrm.10722
Mansard, Catherine Desbleds ; Canet Soulas, Emmanuelle P. ; Anwander, Alfred ; Chaabane, Linda ; Neyran, Bruno ; Serfaty, Jean Michel ; Magnin, Isabelle E. ; Douek, Philippe C. ; Orkisz, Maciej. / Quantification of Multicontrast Vascular MR Images with NLSnake, an Active Contour Model : In Vitro Validation and In Vivo Evaluation. In: Magnetic Resonance in Medicine. 2004 ; Vol. 51, No. 2. pp. 370-379.
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