Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI

M. Bozzali, M. Franceschi, A. Falini, S. Pontesilli, M. Cercignani, G. Magnani, G. Scotti, G. Comi, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

The authors measured mean diffusivity (D) and magnetization transfer ratio (MTR) of the brain from 18 patients with AD and 16 healthy control subjects. The peak heights of cortical gray matter (cGM) D (p <0.001) and MTR (p <0.001) histograms were lower and average cGM D (p <0.01) higher in patients with AD than in control subjects. A composite MR score based on brain volume and cGM MTR peak height was correlated with patient cognitive impairment (r = 0.65, p = 0.003). This preliminary study presents a novel approach to quantify AD-related tissue damage in-vivo.

Original languageEnglish
Pages (from-to)1135-1137
Number of pages3
JournalNeurology
Volume57
Issue number6
Publication statusPublished - Sep 25 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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