Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy

E. Mezzenga, V. D'Errico, M. D'Arienzo, L. Strigari, K. Panagiota, F. Matteucci, S. Severi, G. Paganelli, A. Fenwick, D. Bianchini, F. Marcocci, A. Sarnelli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this study is to investigate the optimal reference geometry for gamma camera calibration. Yet another question of interest was to assess the influence of the number of 3D Ordered Subsets Expectation Maximization (3D-OSEM) updates on activity quantification for SPECT imaging with 177Lu. The accuracy of 177Lu activity quantification was assessed both in small and in large objects. Two different reference geometries, namely a cylindrical homogeneous phantom and a Jaszczak 16 ml sphere surrounded by cold water, were used to determine the gamma camera calibration factor of a commercial SPECT/CT system. Moreover, the noise level and the concentration recovery coefficient were evaluated as a function of the number of 3D-OSEM updates by using the SPECT/CT images of the reference geometry phantoms and those of a cold Jaszczak phantom with three hot spheres (16ml, 8ml and 4ml), respectively. The optimal choice of the number of 3D-OSEM updates was based on a compromise between the noise level achievable in the reconstructed SPECT images and the concentration recovery coefficients. The quantitative accuracy achievable was finally validated on a test phantom, where a spherical insert composed of two concentric spheres was used to simulate a lesion in a warm background. Our data confirm and extend previous observations. Using the calibration factor obtained with the cylindrical homogeneous phantom and the Jaszczak 16 ml sphere, the recovered activity in the test phantom was underestimated by -16.4% and -24.8%, respectively. Our work has led us to conclude that gamma camera calibration performed with large homogeneous phantom outperforms calibration executed with the Jaszczak 16ml sphere. Furthermore, the results obtained support the assumption that approximately 50 OSEM updates represent a good trade-off to reach convergence in small volumes, meanwhile minimizing the noise level.
Original languageEnglish
Pages (from-to)e0182888
JournalPLoS One
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 14 2017

Fingerprint

Molecular Imaging
Radiotherapy
radiotherapy
Single-Photon Emission-Computed Tomography
Calibration
calibration
Gamma Cameras
image analysis
Imaging techniques
Set theory
cameras
Noise
Cameras
Geometry
Recovery
testing
Water
geometry
water

Keywords

  • Calibration
  • Lutetium/chemistry
  • Phantoms, Imaging
  • Radioisotopes/chemistry
  • Radiotherapy
  • Reproducibility of Results
  • Tomography, Emission-Computed, Single-Photon/methods
  • Tomography, X-Ray Computed

Cite this

Mezzenga, E., D'Errico, V., D'Arienzo, M., Strigari, L., Panagiota, K., Matteucci, F., ... Sarnelli, A. (2017). Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy. PLoS One, 12(8), e0182888. https://doi.org/10.1371/journal.pone.0182888 [doi]

Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy. / Mezzenga, E.; D'Errico, V.; D'Arienzo, M.; Strigari, L.; Panagiota, K.; Matteucci, F.; Severi, S.; Paganelli, G.; Fenwick, A.; Bianchini, D.; Marcocci, F.; Sarnelli, A.

In: PLoS One, Vol. 12, No. 8, 14.08.2017, p. e0182888.

Research output: Contribution to journalArticle

Mezzenga, E, D'Errico, V, D'Arienzo, M, Strigari, L, Panagiota, K, Matteucci, F, Severi, S, Paganelli, G, Fenwick, A, Bianchini, D, Marcocci, F & Sarnelli, A 2017, 'Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy', PLoS One, vol. 12, no. 8, pp. e0182888. https://doi.org/10.1371/journal.pone.0182888 [doi]
Mezzenga E, D'Errico V, D'Arienzo M, Strigari L, Panagiota K, Matteucci F et al. Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy. PLoS One. 2017 Aug 14;12(8):e0182888. https://doi.org/10.1371/journal.pone.0182888 [doi]
Mezzenga, E. ; D'Errico, V. ; D'Arienzo, M. ; Strigari, L. ; Panagiota, K. ; Matteucci, F. ; Severi, S. ; Paganelli, G. ; Fenwick, A. ; Bianchini, D. ; Marcocci, F. ; Sarnelli, A. / Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy. In: PLoS One. 2017 ; Vol. 12, No. 8. pp. e0182888.
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