Quantitative analysis of 90Y Bremsstrahlung SPECT-CT images for application to 3D patient-specific dosimetry

Cinzia Fabbri, Graziella Sarti, Marta Cremonesi, Mahila Ferrari, Amalia Di Dia, Monica Agostini, Francesca Botta, Giovanni Paganelli

Research output: Contribution to journalArticlepeer-review


Aim: The aim of this study was to evaluate the accuracy of the activity quantification of single-photon emission computed tomography/computed tomography (SPECT-CT) 90Y-Bremsstrahlung images and to validate the S-voxel method. Methods: An anthropomorphic torso phantom with radioactive inserts (90Y) was acquired by SPECT-CT. Constant calibration factors (cps/MBq) for the quantification were evaluated, considering different volume, shape, position inside the phantom, activity concentration and background, and distance from detectors. S-voxel values (EGSnrc) were implemented in MATLAB R0086 USA software. Dose comparisons between S-voxel and the conventional Medical Internal Radiation Dose method were repeated in a group of 11 patients administered with 90Y-DOTATATE. Results: Using the appropriate calibration factors to recover the volume variability, the error about the measurement repeatability and the activity variation was within 4%. The variability of activity quantification, depending on the position in the phantom, detector distance, and background, was 90Y-Bremsstrahlung images and the generation of three-dmensional dose distributions are feasible. The improved analysis of Bremsstrahlung images could have a notable clinical impact, allowing to address the dosimetric verification to patients during the course of therapy.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalCancer Biotherapy and Radiopharmaceuticals
Issue number1
Publication statusPublished - Feb 1 2009


  • Y-radionuclide therapy
  • Bremsstrahlung image quantification
  • Dose-volume histogram (DVH)
  • Voxel dosimetry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology
  • Medicine(all)


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