Abstract
The salvaging of ECC circuit priming blood is essential for reducing the morbidity related to homologous blood transfusions and the importance of this technique is inversely proportionate to the age and weight of the child. In infants, the washing and centrifugation of blood not only drastically reduce the risk of contracting blood-transmitted diseases and cut management costs, but are also of considerable hemodynamic importance, producing a rapid normalization of the patient's hematocrit and hemoglobin and balancing the O 2 consumption/demand ratio. The marketing of miniaturized salvaging devices with 55 ml bowls by Dideco has made possible the recovery of small quantities of blood, so as to normalise the hematic crisis and permit the application of total hemodilution in low-weight patients. The salvaged blood shows an average hematocrit of 52.7±9.7% (max 68.1%) and an average hemoglobin of 17.6±2.9 g/dl (max 20.7 g/dl), and maintains its structural components, osmotic resistance, concentration of intraerythrocytic hemoglobin and mean corpuscular hemoglobin all intact. Washing with isoosmotic and isoionic hydroelectrolytic solutions normalizes the ionic situation in the post-operative period and activated blood salvaging after Extracorporeal Circulation. The use of solutions without nutritional substances results however in a considerable fall in the number of enzymes in the intraerythrocytic metabolic glucide chain (G 6PDH: -40.7±14.3% p
| Original language | English |
|---|---|
| Pages (from-to) | 398-406 |
| Number of pages | 9 |
| Journal | International Journal of Artificial Organs |
| Volume | 23 |
| Issue number | 6 |
| Publication status | Published - Jun 2000 |
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Keywords
- Cardiopulmonary bypass
- Child
- Extracorporeal circulation
- Hemostasis
- Human
- Infant
ASJC Scopus subject areas
- Biophysics
Cite this
Quantitative and qualitative evaluation of blood salvaged after extracorporeal circulation (ECC) in paediatric heart surgery : Study of biochemical, morphological and structural variations of RBC after ECC and after salvaging of ECC circuit priming blood. / Calza, G.; Zannini, L.; Lerzo, F.; Nitti, P.; Mangraviti, S.; Perutelli, P.; Porlezza, M.
In: International Journal of Artificial Organs, Vol. 23, No. 6, 06.2000, p. 398-406.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative and qualitative evaluation of blood salvaged after extracorporeal circulation (ECC) in paediatric heart surgery
T2 - Study of biochemical, morphological and structural variations of RBC after ECC and after salvaging of ECC circuit priming blood
AU - Calza, G.
AU - Zannini, L.
AU - Lerzo, F.
AU - Nitti, P.
AU - Mangraviti, S.
AU - Perutelli, P.
AU - Porlezza, M.
PY - 2000/6
Y1 - 2000/6
N2 - The salvaging of ECC circuit priming blood is essential for reducing the morbidity related to homologous blood transfusions and the importance of this technique is inversely proportionate to the age and weight of the child. In infants, the washing and centrifugation of blood not only drastically reduce the risk of contracting blood-transmitted diseases and cut management costs, but are also of considerable hemodynamic importance, producing a rapid normalization of the patient's hematocrit and hemoglobin and balancing the O 2 consumption/demand ratio. The marketing of miniaturized salvaging devices with 55 ml bowls by Dideco has made possible the recovery of small quantities of blood, so as to normalise the hematic crisis and permit the application of total hemodilution in low-weight patients. The salvaged blood shows an average hematocrit of 52.7±9.7% (max 68.1%) and an average hemoglobin of 17.6±2.9 g/dl (max 20.7 g/dl), and maintains its structural components, osmotic resistance, concentration of intraerythrocytic hemoglobin and mean corpuscular hemoglobin all intact. Washing with isoosmotic and isoionic hydroelectrolytic solutions normalizes the ionic situation in the post-operative period and activated blood salvaging after Extracorporeal Circulation. The use of solutions without nutritional substances results however in a considerable fall in the number of enzymes in the intraerythrocytic metabolic glucide chain (G 6PDH: -40.7±14.3% p
AB - The salvaging of ECC circuit priming blood is essential for reducing the morbidity related to homologous blood transfusions and the importance of this technique is inversely proportionate to the age and weight of the child. In infants, the washing and centrifugation of blood not only drastically reduce the risk of contracting blood-transmitted diseases and cut management costs, but are also of considerable hemodynamic importance, producing a rapid normalization of the patient's hematocrit and hemoglobin and balancing the O 2 consumption/demand ratio. The marketing of miniaturized salvaging devices with 55 ml bowls by Dideco has made possible the recovery of small quantities of blood, so as to normalise the hematic crisis and permit the application of total hemodilution in low-weight patients. The salvaged blood shows an average hematocrit of 52.7±9.7% (max 68.1%) and an average hemoglobin of 17.6±2.9 g/dl (max 20.7 g/dl), and maintains its structural components, osmotic resistance, concentration of intraerythrocytic hemoglobin and mean corpuscular hemoglobin all intact. Washing with isoosmotic and isoionic hydroelectrolytic solutions normalizes the ionic situation in the post-operative period and activated blood salvaging after Extracorporeal Circulation. The use of solutions without nutritional substances results however in a considerable fall in the number of enzymes in the intraerythrocytic metabolic glucide chain (G 6PDH: -40.7±14.3% p
KW - Cardiopulmonary bypass
KW - Child
KW - Extracorporeal circulation
KW - Hemostasis
KW - Human
KW - Infant
UR - http://www.scopus.com/inward/record.url?scp=0033942194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033942194&partnerID=8YFLogxK
M3 - Article
VL - 23
SP - 398
EP - 406
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
SN - 0391-3988
IS - 6
ER -