Quantitative appraisal of the Amyloid Imaging Taskforce appropriate use criteria for amyloid-PET

D. Altomare, C. Ferrari, C. Festari, U.P. Guerra, C. Muscio, A. Padovani, G.B. Frisoni, M. Boccardi, Incremental Diagnostic Value of Amyloid PET With [18F]-Florbetapir (INDIA-FBP) Working Group

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We test the hypothesis that amyloid–positron emission tomography prescriptions, considered appropriate based on the Amyloid Imaging Taskforce (AIT) criteria, lead to greater clinical utility than AIT-inappropriate prescriptions. Methods: We compared the clinical utility between patients who underwent amyloid–positron emission tomography appropriately or inappropriately and among the subgroups of patients defined by the AIT criteria. Finally, we performed logistic regressions to identify variables associated with clinical utility. Results: We identified 171 AIT-appropriate and 67 AIT-inappropriate patients. AIT-appropriate and AIT-inappropriate cases did not differ in any outcomes of clinical utility (P >.05). Subgroup analysis denoted both expected and unexpected results. The logistic regressions outlined the primary role of clinical picture and clinical or neuropsychological profile in identifying patients benefitting from amyloid–positron emission tomography. Discussion: Contrary to our hypothesis, also AIT-inappropriate prescriptions were associated with clinical utility. Clinical or neuropsychological variables, not taken into account by the AIT criteria, may help further refine criteria for appropriateness. © 2018 the Alzheimer's Association
Original languageEnglish
Pages (from-to)1088-1098
Number of pages11
JournalAlzheimer's and Dementia
Volume14
Issue number8
DOIs
Publication statusPublished - 2018

Keywords

  • amyloid
  • florbetapir f 18
  • aged
  • Alzheimer disease
  • Alzheimer Disease Assessment Scale
  • Article
  • clinical feature
  • cognition
  • controlled study
  • dementia
  • diagnostic value
  • disease association
  • female
  • frontotemporal dementia
  • human
  • inappropriate prescribing
  • major clinical study
  • male
  • Mini Mental State Examination
  • neuropsychology
  • outcome assessment
  • positron emission tomography
  • practice guideline
  • prevalence
  • priority journal
  • Profile of Elderly Quality of Life
  • quality of life assessment
  • quantitative analysis
  • retrospective study
  • sleep disorder

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