Quantitative approach to regional blood flow distribution and wall motion using microsphere myocardial scintigraphy in man

Paolo Marzullo, Claudio Marcassa, Oberdan Parodi, Gianmario Sambuceti, Ezio Maria Ferdeghini, Roberto Testa, Antonio L'Abbate

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A method for quantitative analysis of perfusion and wall motion applied to electrocardiogram-gated images of myocardial 99 mTc albumin microspheres of 99 mTc methoxyisobutil isonitrile, implemented on an Elscint 410M Apex computer system, is described. Quantitative myocardial perfusion was obtained via the ratio between end-diastolic normal reference and patient's angular profiles. A wall thickening index (WTI) was obtained obeying the formula: ((end-systolic profile-end-diastolic profile)/end-diastolic profile) × 100. Compared with regional fractional shortening obtained from biplane contrast ventriculography, microsphere WTI showed sensitivity of 97% and a specificity of 93%. WTI values for methoxyisobutil isonitrile were 82% and 94%, respectively. The proposed count-based method provides simultaneous information on regional perfusion and wall motion.

Original languageEnglish
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages115-118
Number of pages4
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

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    Marzullo, P., Marcassa, C., Parodi, O., Sambuceti, G., Ferdeghini, E. M., Testa, R., & L'Abbate, A. (1987). Quantitative approach to regional blood flow distribution and wall motion using microsphere myocardial scintigraphy in man. In Computers in Cardiology (pp. 115-118). Publ by IEEE.