Quantitative assessment of erythropoiesis in hemolytic disease

M. Stefanelli, G. Barosi, M. Cazzola, E. Orlandi

Research output: Contribution to journalArticle

Abstract

Erythrokinetic parameters were estimated in 21 patients suffering from hemolytic disease using a mathematical model of iron kinetics. A proper definition of radioiron reflux from red cells to the plasma proved to be essential for an accurate estimate of effective and ineffective erythropoiesis in severe hemolytic conditions. Erythropoietic activity was increased in all the patients, with the marrow capable of sustaining erythropoiesis at about 6 times normal in hereditary spherocytosis and 3 times normal in autoimmune hemolytic anemia. This proliferative effort was countered by an increase in ineffective erythropoiesis which was especially marked in hereditary spherocytosis.

Original languageEnglish
Pages (from-to)297-308
Number of pages12
JournalBritish Journal of Haematology
Volume45
Issue number2
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Hematology

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