All materials employed for clinical implants, including biomaterials used in plastic surgery, should be previously tested for biocompatibility. Each biomaterial is studied following a four evaluation step protocol as follows: 19 screening tests; 2) supplementary tests; 3) infectibility tests; 4)structural tests. The basic pattern is continuously modified according to type of material, use and acquired data. Silicone used in plastic surgery has been tested with: screening for toxicity using established line fibroblasts; cellular response using lymphocyte culture through activation and proliferation quantitative tests; histocompatibility evaluation on perimplant tissue samples collected during breast prosthesis revision; immunocompatibility tests; infectibility evaluation through studies of bacterial adhesion. In our hands, silicone proved to be well tolerated by both cells and tissues. Moreover, it does not seem to produce lymphocyte activation. Silicone gel causes a greater bacterial adhesion than silicone elastomer.
|Translated title of the contribution||Quantitative biocompatibility of materials used in plastic surgery|
|Number of pages||8|
|Journal||Rivista Italiana di Chirurgia Plastica|
|Issue number||1 SUPPL.|
|Publication status||Published - 1994|
ASJC Scopus subject areas