VALUTAZIONE QUANTITATIVA DELLA BIOCOMPATIBILITA DI MATERIALI IMPIEGATI IN CHIRURGIA PLASTICA

Translated title of the contribution: Quantitative biocompatibility of materials used in plastic surgery

A. Pizzoferrato, C. R. Arciola, E. Cenni, G. Ciapetti, D. Granchi, L. Savarino, S. Stea

Research output: Contribution to journalArticlepeer-review

Abstract

All materials employed for clinical implants, including biomaterials used in plastic surgery, should be previously tested for biocompatibility. Each biomaterial is studied following a four evaluation step protocol as follows: 19 screening tests; 2) supplementary tests; 3) infectibility tests; 4)structural tests. The basic pattern is continuously modified according to type of material, use and acquired data. Silicone used in plastic surgery has been tested with: screening for toxicity using established line fibroblasts; cellular response using lymphocyte culture through activation and proliferation quantitative tests; histocompatibility evaluation on perimplant tissue samples collected during breast prosthesis revision; immunocompatibility tests; infectibility evaluation through studies of bacterial adhesion. In our hands, silicone proved to be well tolerated by both cells and tissues. Moreover, it does not seem to produce lymphocyte activation. Silicone gel causes a greater bacterial adhesion than silicone elastomer.

Translated title of the contributionQuantitative biocompatibility of materials used in plastic surgery
Original languageItalian
Pages (from-to)12-19
Number of pages8
JournalRivista Italiana di Chirurgia Plastica
Volume26
Issue number1 SUPPL.
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Surgery

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