Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis

M. Filippi; M. A. Horsfield; S. P. Morrissey; D. G. MacManus; P. Rudge; W. I. Mc Donald; David H. Miller

Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis

M. Filippi, M. A. Horsfield, S. P. Morrissey, D. G. MacManus, P. Rudge, W. I. Mc Donald, David H. Miller

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We performed semiautomated quantitative measurement of brain magnetic resonance imaging (MRI) abnormalities seen at presentation and at 5-year follow-up in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves, brainstem, or spinal cord suggestive of multiple sclerosis (MS). At follow-up, 34 (40%) had developed clinically definite and four (5%) clinically probable MS. Patients who developed MS during follow-up had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at follow-up. Increasing initial lesion load correlated with a decreasing time to development of MS clinically (r = −0.328, p

Original language	English
Pages (from-to)	635-641
Number of pages	7
Journal	Neurology
Volume	44
Issue number	4
Publication status	Published - 1994

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology
Neuroscience(all)

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title = "Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis",

abstract = "We performed semiautomated quantitative measurement of brain magnetic resonance imaging (MRI) abnormalities seen at presentation and at 5-year follow-up in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves, brainstem, or spinal cord suggestive of multiple sclerosis (MS). At follow-up, 34 (40%) had developed clinically definite and four (5%) clinically probable MS. Patients who developed MS during follow-up had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at follow-up. Increasing initial lesion load correlated with a decreasing time to development of MS clinically (r = −0.328, p ",

author = "M. Filippi and Horsfield, {M. A.} and Morrissey, {S. P.} and MacManus, {D. G.} and P. Rudge and {Mc Donald}, {W. I.} and Miller, {David H.}",

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AU - Filippi, M.

AU - Horsfield, M. A.

AU - Morrissey, S. P.

AU - MacManus, D. G.

AU - Rudge, P.

AU - Mc Donald, W. I.

AU - Miller, David H.

PY - 1994

Y1 - 1994

N2 - We performed semiautomated quantitative measurement of brain magnetic resonance imaging (MRI) abnormalities seen at presentation and at 5-year follow-up in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves, brainstem, or spinal cord suggestive of multiple sclerosis (MS). At follow-up, 34 (40%) had developed clinically definite and four (5%) clinically probable MS. Patients who developed MS during follow-up had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at follow-up. Increasing initial lesion load correlated with a decreasing time to development of MS clinically (r = −0.328, p

AB - We performed semiautomated quantitative measurement of brain magnetic resonance imaging (MRI) abnormalities seen at presentation and at 5-year follow-up in 84 patients presenting with an acute clinically isolated syndrome of the optic nerves, brainstem, or spinal cord suggestive of multiple sclerosis (MS). At follow-up, 34 (40%) had developed clinically definite and four (5%) clinically probable MS. Patients who developed MS during follow-up had a higher lesion load at presentation than those who did not. There was a strong correlation of the MRI lesion load at presentation with both the increase in lesion load over the next 5 years and disability at follow-up. Increasing initial lesion load correlated with a decreasing time to development of MS clinically (r = −0.328, p

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Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis

Abstract

ASJC Scopus subject areas

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