Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis

E Ammirati, Francesco Moroni, Paola Sormani, A Peritore, A Milazzo, Giuseppina Quattrocchi, Manlio Cipriani, Fabrizio Oliva, C Giannattasio, Maria Frigerio, A Roghi, PG Camici, P Pedrotti

Research output: Contribution to journalArticlepeer-review


Background: The presence of late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) has diagnostic and prognostic value in patients with acute myocarditis (AM). Aim of our study was to quantify the changes in LGE extension (LGE%) early after AM and evaluate its relations with biventricular function and morphology. Methods: We investigated 76 consecutive patients with AM (acute onset of chest pain/heart failure/ventricular arrhythmias not explained by other causes, and raised troponin) that met CMR criteria based on myocardial oedema at T2-weighted images and LGE on post-contrast images at median time of 6. days from onset of symptoms. We quantified LGE% at baseline and after 148. days in 49 patients. Results: Median left ventricular (LV)-ejection fraction (EF) was 64% (interquartile range [Q1-Q3]: 56-67%), and LGE% 9.4% (Q1-Q3: 7.5-13.2%). LGE% was correlated with LV end-systolic volume index (LV-ESVi; r. = + 0.34; . p = 0.003). LGE% was inversely correlated with LV-EF (r = -0.31; . p = 0.007) and time to CMR scan (r = -0.25; . p = 0.028). In the 49 patients with a second CMR scan, despite no significant variations in LV-EF, a significant decrease of LGE% was observed (p <0.0001) with a relative reduction of 42% compared with baseline. Patients showing increased LV-ESVi at follow up had a lower decrease of LGE% (p = 0.038). Conclusions: In the acute phase of AM the LGE extension is a dynamic process that reflects impairment of LV function and is time dependent. LGE% appears one of the CMR parameters with the largest relative variations in the first months after AM. © 2016 Elsevier Ireland Ltd.
Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalInternational Journal of Cardiology
Issue number4
Publication statusPublished - 2017


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