Abstract
Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5%. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5%, but with a remarkable range (-40%,+60%) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.
| Original language | English |
|---|---|
| Pages (from-to) | 72-79 |
| Number of pages | 8 |
| Journal | Physica Medica |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Dose distribution
- Dosimetry
- DVH
- Radionuclide therapy
- Voxel
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Physics and Astronomy(all)
- Medicine(all)
Cite this
Quantitative comparison between the commercial software STRATOS®by Philips and a homemade software for voxel-dosimetry in radiopeptide therapy. / Grassi, E.; Fioroni, F.; Ferri, V.; Mezzenga, E.; Sarti, M. A.; Paulus, T.; Lanconelli, N.; Filice, A.; Versari, A.; Iori, M.
In: Physica Medica, Vol. 31, No. 1, 2015, p. 72-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative comparison between the commercial software STRATOS®by Philips and a homemade software for voxel-dosimetry in radiopeptide therapy
AU - Grassi, E.
AU - Fioroni, F.
AU - Ferri, V.
AU - Mezzenga, E.
AU - Sarti, M. A.
AU - Paulus, T.
AU - Lanconelli, N.
AU - Filice, A.
AU - Versari, A.
AU - Iori, M.
PY - 2015
Y1 - 2015
N2 - Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5%. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5%, but with a remarkable range (-40%,+60%) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.
AB - Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5%. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5%, but with a remarkable range (-40%,+60%) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.
KW - Dose distribution
KW - Dosimetry
KW - DVH
KW - Radionuclide therapy
KW - Voxel
UR - http://www.scopus.com/inward/record.url?scp=84923331063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923331063&partnerID=8YFLogxK
U2 - 10.1016/j.ejmp.2014.10.002
DO - 10.1016/j.ejmp.2014.10.002
M3 - Article
C2 - 25457430
AN - SCOPUS:84923331063
VL - 31
SP - 72
EP - 79
JO - Physica Medica
JF - Physica Medica
SN - 1120-1797
IS - 1
ER -