Quantitative comparison between the commercial software STRATOS®by Philips and a homemade software for voxel-dosimetry in radiopeptide therapy

E. Grassi, F. Fioroni, V. Ferri, E. Mezzenga, M. A. Sarti, T. Paulus, N. Lanconelli, A. Filice, A. Versari, M. Iori

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13 Citations (Scopus)

Abstract

Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5%. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5%, but with a remarkable range (-40%,+60%) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalPhysica Medica
Volume31
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

dosimeters
therapy
Software
computer programs
dosage
kidneys
Organs at Risk
Kidney
Therapeutics
Single-Photon Emission-Computed Tomography
Radioisotopes
disintegration
inserts
histograms
organs
radioactive isotopes
planning
inhomogeneity
curves
estimates

Keywords

  • Dose distribution
  • Dosimetry
  • DVH
  • Radionuclide therapy
  • Voxel

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)
  • Medicine(all)

Cite this

@article{288205380e254c7b9bba162bc95dc42e,
title = "Quantitative comparison between the commercial software STRATOS{\circledR}by Philips and a homemade software for voxel-dosimetry in radiopeptide therapy",
abstract = "Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5{\%}. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5{\%}, but with a remarkable range (-40{\%},+60{\%}) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.",
keywords = "Dose distribution, Dosimetry, DVH, Radionuclide therapy, Voxel",
author = "E. Grassi and F. Fioroni and V. Ferri and E. Mezzenga and Sarti, {M. A.} and T. Paulus and N. Lanconelli and A. Filice and A. Versari and M. Iori",
year = "2015",
doi = "10.1016/j.ejmp.2014.10.002",
language = "English",
volume = "31",
pages = "72--79",
journal = "Physica Medica",
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TY - JOUR

T1 - Quantitative comparison between the commercial software STRATOS®by Philips and a homemade software for voxel-dosimetry in radiopeptide therapy

AU - Grassi, E.

AU - Fioroni, F.

AU - Ferri, V.

AU - Mezzenga, E.

AU - Sarti, M. A.

AU - Paulus, T.

AU - Lanconelli, N.

AU - Filice, A.

AU - Versari, A.

AU - Iori, M.

PY - 2015

Y1 - 2015

N2 - Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5%. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5%, but with a remarkable range (-40%,+60%) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.

AB - Background: Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with the software STRATOS. Methods: The validation of both of them was undertaken using radioactive phantoms with different volume inserts. A cohort of 10 patients was also studied after a therapeutic administration of 177Lu-labelled radiopeptides. The activity, number of disintegrations, absorbed dose and dose-volume histogram (DVH) were calculated for the phantoms and the kidneys in patients, which were the main critical organs at risk in this study. Results: In phantoms the absorbed doses computed with VoxelMed and STRATOS agree within 5%. In patients at the voxel-level the absorbed dose to kidneys (VoxelMed: mean 0.66Gy/GBq) showed a limited difference of 5%, but with a remarkable range (-40%,+60%) between the two software packages. Voxel-dosimetry allows to estimate the dose non-homogeneities in volumes, which may be evaluated through DVHs. Conclusion: This study demonstrates that a fully 3D voxel-dosimetry with multiple SPECT images is feasible by using home-made or commercial software package and absorbed dose results obtained are similar. The main difference between the studied tools was observed in the activity integration method (effective vs physical half-time to time activity curve tail). We believe that an effective half-time integration method produces a more accurate approximation of clinical uptake and resultant dosimetry.

KW - Dose distribution

KW - Dosimetry

KW - DVH

KW - Radionuclide therapy

KW - Voxel

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