Quantitative correlation between carcinogenicity and sister chromatid exchange induction in vivo for a group of 11 /v-nitroso derivatives

Silvio Parodi, Annalisa Zimino, Laura Ottaggio, Marcella De Ferrari, Leonardo Santi

Research output: Contribution to journalArticlepeer-review

Abstract

The quantitative correlation between induction of sister chromatid exchanges (SCEs) in vivo and carcinogenic potency was examined for 11 nitroso derivatives and was compared with the correlation of alkaline DNA fragmentation in liver DNA in vivo and with the Ames test. The correlation between DNA adducts and SCEs was also evaluated. DNA damage was slightly more predictive and the Ames test less predictive than SCE evaluation. The predictivity of these tests for this class of compounds was compared with the predictivity shown for different classes of chemical compounds.

Original languageEnglish
Pages (from-to)337
Number of pages1
JournalJournal of Toxicology and Environmental Health
Volume11
Issue number3
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Toxicology
  • Pollution

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