TY - JOUR
T1 - Quantitative correlation between carcinogenicity and sister chromatid exchange induction in vivo for a group of 11 /v-nitroso derivatives
AU - Parodi, Silvio
AU - Zimino, Annalisa
AU - Ottaggio, Laura
AU - De Ferrari, Marcella
AU - Santi, Leonardo
PY - 1983
Y1 - 1983
N2 - The quantitative correlation between induction of sister chromatid exchanges (SCEs) in vivo and carcinogenic potency was examined for 11 nitroso derivatives and was compared with the correlation of alkaline DNA fragmentation in liver DNA in vivo and with the Ames test. The correlation between DNA adducts and SCEs was also evaluated. DNA damage was slightly more predictive and the Ames test less predictive than SCE evaluation. The predictivity of these tests for this class of compounds was compared with the predictivity shown for different classes of chemical compounds.
AB - The quantitative correlation between induction of sister chromatid exchanges (SCEs) in vivo and carcinogenic potency was examined for 11 nitroso derivatives and was compared with the correlation of alkaline DNA fragmentation in liver DNA in vivo and with the Ames test. The correlation between DNA adducts and SCEs was also evaluated. DNA damage was slightly more predictive and the Ames test less predictive than SCE evaluation. The predictivity of these tests for this class of compounds was compared with the predictivity shown for different classes of chemical compounds.
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U2 - 10.1080/15287398309530347
DO - 10.1080/15287398309530347
M3 - Article
C2 - 6842616
AN - SCOPUS:0020558186
VL - 11
SP - 337
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
SN - 1528-7394
IS - 3
ER -