Quantitative detection of HHV-6 and HHV-7 in transbronchial biopsies from lung transplant recipients

Cristina Costa, Antonio Curtoni, Massimiliano Bergallo, Paolo Solidoro, Mariangela Lorusso, Luisa Delsedime, Anna Sapino, Rossana Cavallo

Research output: Contribution to journalArticle

Abstract

The occurrence and significance of HHV-6 and HHV-7 were investigated in pulmonary tissue from lung transplant recipients. Eighty-seven transbronchial biopsies from 30 patients were studied by quantitative real-time PCR; the association with histopathological features was investigated. HHV-6 and HHV-7-DNA were detected in 6.9% and 9.2% transbronchial biopsies, respectively. A significant association between HHV-6 detection on transbronchial biopsies and interstitial pneumonia was found, in contrast to the lack of association between viral detection on bronchoalveolar lavage and any histopathological feature. No association was evidenced in terms of acute and chronic rejection. The finding of HHV-6 and/or HHV-7-DNA positivity in all the cases with ischemia-reperfusion injury suggests a possible role in favouring β-herpesviruses reactivation, as previously described for HCMV in renal transplantation.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalNew Microbiologica
Volume34
Issue number3
Publication statusPublished - Jul 2011

Keywords

  • Human herpesvirus 6
  • Human herpesvirus 7
  • Lung transplantation
  • Transbronchial biopsy

ASJC Scopus subject areas

  • Microbiology (medical)

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  • Cite this

    Costa, C., Curtoni, A., Bergallo, M., Solidoro, P., Lorusso, M., Delsedime, L., Sapino, A., & Cavallo, R. (2011). Quantitative detection of HHV-6 and HHV-7 in transbronchial biopsies from lung transplant recipients. New Microbiologica, 34(3), 275-280.