Quantitative EEG and autonomic patterns of synthetic peptides related to dermorphin

E. Marchioni, M. Maurelli, A. Tartara

Research output: Contribution to journalArticle

Abstract

The effects of dermorphin on EEG and autonomic variables are compared with the effects of 2 analogues and 2 homologues, all administered intracerebroventricularly in the rabbit. Dermorphin was the most effective in modifying all considered parameters: increase of cortically derived and calculated total power, bradycardia, respiratory depression and hypothermia. The dibenzylated heptapeptide was essentially inactive. The electrocortical pattern induced by the administration of L-dermorphin suggests a functional correlation between the amino acid D-ala 2 and the effects on EEG. Comparison between the effects produced by the N-terminal tetrapeptide and pentapeptide led us to hypothesize that amino acid Tyr 5 may be specifically involved in inducing the autonomic effects.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalNeuropsychobiology
Volume26
Issue number1-2
Publication statusPublished - 1992

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Keywords

  • Autonomic functions
  • Computerized EEG
  • Dermorphin
  • Dermorphin-related peptides

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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