Quantitative EEG and perfusional single photon emission computed tomography correlation during long-term donepezil therapy in Alzheimer's disease

Guido Rodriguez, Paolo Vitali, Michela Canfora, Piero Calvini, Nicola Girtler, Caterina De Leo, Arnoldo Piccardo, Flavio Nobili

Research output: Contribution to journalArticle

Abstract

Objective: There is an increasing interest in the effects of the acetylcholinesterase inhibitors (AChEIs) in Alzheimer's disease (AD), as investigated by means of objective, neurophysiological tools. In an open-label study, we evaluated the neurophysiological effects of chronic administration of donepezil to AD patients, by means of a correlative approach between quantitative EEG (qEEG) and perfusional brain single photon emission computed tomography (SPECT). Methods: Sixteen patients (mean age: 74.8±7.9 years) with mild to moderate AD (MMSE score 13, mean: 20.7±4.6) underwent qEEG and SPECT examinations at the time of diagnosis (t0) and after approximately 1 year of donepezil therapy (t1). The brain SPECT (99mTc-hexamethylpropyleneamine oxime) was performed by means of a high-resolution SPECT camera; the qEEG was recorded from 19 scalp electrodes by average reference and digitized at 512 Hz. The mean frequency (MF) value of the mean power spectrum (fast Fourier transform) from 4 brain regions (one frontal and one temporal-parietal in each hemisphere) was chosen for statistical analysis. Changes in MMSE score and qEEG-MF values between t0 and t1 were assessed by analysis of variance. SPECT differences between t0 and t1, as well as the relationships between SPECT and qEEG changes, were assessed by statistical parametric mapping (SPM 99; height threshold: P=0.001 at cluster level). Results: Between t0 and t 1, the MMSE score significantly (P

Original languageEnglish
Pages (from-to)39-49
Number of pages11
JournalClinical Neurophysiology
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Acetylcholinesterase inhibitor
  • Alzheimer's disease
  • Brain single photon emission computed tomography
  • Donepezil
  • Quantitative EEG
  • Statistical parametric mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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