Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies

Laura Bonanni, Bernardo Perfetti, Stefania Bifolchetti, John Paul Taylor, Raffaella Franciotti, Lucilla Parnetti, Astrid Thomas, Marco Onofrj

Research output: Contribution to journalArticlepeer-review

Abstract

Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB. Quantitative electroencephalogram (QEEG) methods are able to differentiate early DLB from Alzheimer's disease (AD). The aim of the present study was to assess whether QEEG abnormalities, characterized by dominant frequency 1.5Hz, typical of early DLB, are already present at the stage of MCI and to evaluate whether EEG abnormalities can predict the development of DLB. Forty-seven MCI subjects were followed for 3years. EEG recordings were obtained at admission and at the end of the study. At the end of follow-up, 20 subjects had developed probable DLB (MCI-DLB), 14 had probable AD (MCI-AD), 8 did not convert to dementia, 5 developed a non-AD/DLB dementia. One hundred percent of MCI-DLB showed EEG abnormalities at admission. Ninety three percent of MCI-AD maintained a normal EEG throughout the study. QEEG may represent a powerful tool to predict the progression from MCI to DLB with a sensitivity and specificity close to 100%.

Original languageEnglish
Pages (from-to)434-445
Number of pages12
JournalNeurobiology of Aging
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Dementia with Lewy bodies
  • Mild cognitive impairment
  • Quantitative EEG

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

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