Quantitative evaluation for brain CT/MRI coregistration based on maximization of mutual information in patients with focal epilepsy investigated with subdural electrodes

Soléakhéna Ken, Giancarlo Di Gennaro, Giovanni Giulietti, Fabio Sebastiano, Diego De Carli, Girolamo Garreffa, Claudio Colonnese, Roberto Passariello, Jean Albert Lotterie, Bruno Maraviglia

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with drug-resistant focal epilepsy may require intracranial investigations with subdural electrodes. These must be correctly localized with respect to the brain cortical surface and require appropriate monitoring. For this purpose, coregistration techniques, which fuse preimplantation 3D magnetic resonance imaging scans with postimplantation computed tomography scans, have been implemented. In order to reduce localization errors due to the fusion process, we used a coregistration method based on the maximization of mutual information (MI) in 11 patients with extratemporal epilepsy who were invasively investigated. Our registration method is based on three processing steps: rigid-body transformation for coregistration, computation of MI as a similarity measure and the use of the Downhill Simplex optimization method. After consistency analysis, the shift of the registration method reached 0.14±0.27 mm in translation and 0.03±0.14° in rotation, and the accuracies assessed on voxels of skull surface and voxels of the center of the brain volume were 1.42±0.61 and 1.15±0.53 mm, respectively. The accuracy of the fusion process reached submillimeter range, and results were considered reliable for surgical planning in all studied patients.

Original languageEnglish
Pages (from-to)883-888
Number of pages6
JournalMagnetic Resonance Imaging
Volume25
Issue number6
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Coregistration
  • CT
  • Drug-resistant focal epilepsy
  • MRI
  • Multimodal
  • Mutual information

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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