Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung

Sara Mohammadi, Emanuel Larsson, Frauke Alves, Simeone Dal Monego, Stefania Biffi, Chiara Garrovo, Andrea Lorenzon, Giuliana Tromba, Christian Dullin

Research output: Contribution to journalArticle

Abstract

Propagation-based X-ray phase-contrast computed tomography (PBI) has already proven its potential in a great variety of soft-tissue-related applications including lung imaging. However, the strong edge enhancement, caused by the phase effects, often hampers image segmentation and therefore the quantitative analysis of data sets. Here, the benefits of applying single-distance phase retrieval prior to the three-dimensional reconstruction (PhR) are discussed and quantified compared with three-dimensional reconstructions of conventional PBI data sets in terms of contrast-to-noise ratio (CNR) and preservation of image features. The PhR data sets show more than a tenfold higher CNR and only minor blurring of the edges when compared with PBI in a predominately absorption-based set-up. Accordingly, phase retrieval increases the sensitivity and provides more functionality in computed tomography imaging.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalJournal of Synchrotron Radiation
Volume21
Issue number4
DOIs
Publication statusPublished - 2014

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Keywords

  • computed tomography
  • lung imaging
  • phase retrieval
  • phase-contrast imaging

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics
  • Radiation
  • Medicine(all)

Cite this

Mohammadi, S., Larsson, E., Alves, F., Dal Monego, S., Biffi, S., Garrovo, C., Lorenzon, A., Tromba, G., & Dullin, C. (2014). Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung. Journal of Synchrotron Radiation, 21(4), 784-789. https://doi.org/10.1107/S1600577514009333