Quantitative evaluation of saccadic Eye movements: Effect of aging and clinical use

Saccadic eye movement analysis is becoming increasingly quantitative; thus, an appropriate statistical methodology is needed both for normative data and for single subject evaluation. By assessing normative data in 76 healthy subjects, the authors demonstrated that the amplitude/duration (A/D) and amplitude/peak velocity (A/Vp) relationships, as well as latency, are age-dependent. They did not find a relationship between precision and, respectively, age and target offset. Accordingly, they propose that single subject evaluation should be based on A/D and A/Vp relationships in their entirety, with both the mean and distribution of individual values as the basis for precision and latency.