Quantitative magnetization transfer imaging as a biomarker for effects of Systemic inflammation on the brain

Neil A. Harrison, Ella Cooper, Nicholas G. Dowell, Georgia Keramida, Valerie Voon, Hugo D. Critchley, Mara Cercignani

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Systemic inflammation impairs brain function and is increasingly implicated in the etiology of common mental illnesses, particularly depression and Alzheimer's disease. Immunotherapies selectively targeting proinflammatory cytokines demonstrate efficacy in a subset of patients with depression. However, efforts to identify patients most vulnerable to the central effects of inflammation are hindered by insensitivity of conventional structural magnetic resonance imaging. METHODS: We used quantitative magnetization transfer (qMT) imaging, a magnetic resonance imaging technique that enables quantification of changes in brain macromolecular density, together with experimentally induced inflammation to investigate effects of systemic inflammatory challenge on human brain microstructure. Imaging with qMT was performed in 20 healthy participants after typhoid vaccination and saline control injection. An additional 20 participants underwent fluorodeoxyglucose positron emission tomography following the same inflammatory challenge. RESULTS: The qMT data demonstrated that inflammation induced a rapid change in brain microstructure, reflected in increased magnetization exchange from free (water) to macromolecular-bound protons, within a discrete region of insular cortex implicated in representing internal physiologic states including inflammation. The functional significance of this change in insular microstructure was demonstrated by correlation with inflammation-induced fatigue and fluorodeoxyglucose positron emission tomography imaging, which revealed increased resting glucose metabolism within this region following the same inflammatory challenge. CONCLUSIONS: Together these observations highlight a novel structural biomarker of the central physiologic and behavioral effects of mild systemic inflammation. The widespread clinical availability of magnetic resonance imaging supports the viability of qMT imaging as a clinical biomarker in trials of immunotherapeutics, both to identify patients vulnerable to the effects of systemic inflammation and to monitor neurobiological responses.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalBiological Psychiatry
Volume78
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Encephalitis
Biomarkers
Inflammation
Magnetic Resonance Imaging
Positron-Emission Tomography
Brain
Depression
Typhoid Fever
Cerebral Cortex
Immunotherapy
Fatigue
Protons
Healthy Volunteers
Alzheimer Disease
Vaccination
Cytokines
Glucose
Injections
Water

Keywords

  • Biomarker
  • Cytokine
  • Depression
  • Fatigue
  • Inflammation
  • Insula
  • MRI

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Quantitative magnetization transfer imaging as a biomarker for effects of Systemic inflammation on the brain. / Harrison, Neil A.; Cooper, Ella; Dowell, Nicholas G.; Keramida, Georgia; Voon, Valerie; Critchley, Hugo D.; Cercignani, Mara.

In: Biological Psychiatry, Vol. 78, No. 1, 2015, p. 49-57.

Research output: Contribution to journalArticle

Harrison, Neil A. ; Cooper, Ella ; Dowell, Nicholas G. ; Keramida, Georgia ; Voon, Valerie ; Critchley, Hugo D. ; Cercignani, Mara. / Quantitative magnetization transfer imaging as a biomarker for effects of Systemic inflammation on the brain. In: Biological Psychiatry. 2015 ; Vol. 78, No. 1. pp. 49-57.
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