Quantitative Magnetization Transfer of White Matter Tracts Correlates with Diffusion Tensor Imaging Indices in Predicting the Conversion from Mild Cognitive Impairment to Alzheimer's Disease

Elena Makovac, Laura Serra, Carlotta Di Domenico, Camillo Marra, Carlo Caltagirone, Mara Cercignani, Marco Bozzali

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with amnestic mild cognitive impairment (aMCI) have higher probability to develop Alzheimer's disease (AD) than elderly controls. The detection of subtle changes in brain structure associated with disease progression and the development of tools to identify patients at high risk for dementia in a short time is crucial. Here, we used probabilistic white matter (WM) tractography to explore microstructural alterations within the main association, limbic, and commissural pathways in aMCI patients who converted to AD after 1 year follow-up (MCI converters) and those who remained stable (MCI stable). Both diffusion tensor imaging (DTI) and quantitative magnetization transfer (qMT) parameters have been considered for a comprehensive pathophysiological characterization of the WM damage. Overall, tract-specific parameters derived from qMT and DTI at baseline were able to differentiate aMCI patients who converted to AD from those who remained stable in time. In particular, the qMT exchange rate, RM B 0, of the right uncinate fasciculus was significantly decreased in MCI converters, whereas fractional anisotropy was significantly decreased in the bilateral superior cingulum in MCI converters compared to MCI stable. These results confirm the involvement of WM and particularly of association fibers in the progression of AD, highlighting disconnection as a potential mechanism.

Original languageEnglish
Pages (from-to)561-575
Number of pages15
JournalJournal of Alzheimer's Disease
Volume63
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Diffusion tensor imaging
  • mild cognitive impairment
  • probabilistic tractography
  • quantitative magnetization transfer
  • white matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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