Quantitative MR markers and psychiatric symptoms in a patient with Fahr disease

Viviana Lo Buono, Francesco Corallo, Antonio Costa, Placido Bramanti, Silvia Marino

Research output: Contribution to journalArticle

Abstract

Objective: Rare disease Background: Fahr’s disease (FD), or primitive idiopathic calcification of the basal ganglia, is a rare neurodegenerative syndrome characterized by the presence of idiopathic bilateral and symmetrical cerebral calcifications. Case Report: We describe the case of 43-year-old woman presenting with psychiatric symptoms, disorganized behavior, and migraine. Magnetic resonance imaging (MRI) examination showed basal ganglia calcifications. In addition, we analyzed the cortical brain volume and noted cortical atrophy. Extensive etiological clinico-biological assessment allowed us to exclude known causes of brain calcifications and to diagnose Fahr disease (FD). Neurological symptoms associated with psychiatric manifestations are not uncommon in FD. Conclusions: Purely psychiatric presentations are possible, as demonstrated by the present case, although there have been very few cases reported. To date, no studies related to the brain atrophy in FD have been reported.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalAmerican Journal of Case Reports
Volume16
DOIs
Publication statusPublished - Jun 21 2015

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Psychiatry
Basal Ganglia
Atrophy
Brain
Rare Diseases
Migraine Disorders
Magnetic Resonance Imaging

Keywords

  • Basal ganglia
  • Psychiatry
  • Thalamus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Quantitative MR markers and psychiatric symptoms in a patient with Fahr disease. / Lo Buono, Viviana; Corallo, Francesco; Costa, Antonio; Bramanti, Placido; Marino, Silvia.

In: American Journal of Case Reports, Vol. 16, 21.06.2015, p. 382-385.

Research output: Contribution to journalArticle

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