Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis.

Chiara Giulia FontanellaThese Authors Equally Contributed To The, Elisa Belluzzi, Marco Rossato, Eleonora Olivotto, Giovanni Trisolino, Pietro Ruggieri, Alessandro Rubini, Andrea Porzionato, Arturo Natali, Raffaele De Caro, Roberto Vettor, Roberta Ramonda, Veronica Macchi, Marta Favero

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Abstract

The aim of this study was to analyze the magnetic resonance imaging (MRI) volumetric and morphometric characteristics of the infrapatellar fat pad (IFP) and the suprapatellar fat pad (SFP) in normal controls, moderate and end-stage osteoarthritis (OA) patients. Forty-four MRI images of the three groups were collected: a) 17 patients undergoing meniscectomy with Outerbridge score 0 (control group); b) 15 patients undergoing meniscectomy with Outerbridge score 3/4 (moderate OA group); and c) 12 patients undergoing total knee replacement (end-stage OA group). Volume, depth, femoral and tibial arch lengths of IFP were quantified. The hypointense IFP signals were also scored. The SFP volume, oblique, antero-posterior and, cranio-caudal lengths were determined. IFP and SFP characteristics were compared between groups. A decrease of IFP volume, depth, femoral, and tibial arch lengths in moderate and end-stage OA compared to controls were observed. A difference in IFP hypointense signal was found between groups. No differences were found in SFP characteristics between the groups. In controls and moderate OA patients, correlations were found among the different MRI characteristics of both IFP and SFP, while in the end-stage OA group correlations were found only in SFP. We evidenced differences of the IFP MRI morphometric characteristics between the groups analyzed, supporting an important role of IFP in OA pathology and progression. On the contrary, no differences were highlighted in SFP analysis suggesting that this fat pad is not clearly involved in OA, probably due to its peculiar localization and different function.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalAnnals of Anatomy
Volume221
DOIs
Publication statusE-pub ahead of print - Oct 2018

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Osteoarthritis
Adipose Tissue
Magnetic Resonance Imaging
Thigh
Knee Replacement Arthroplasties

Keywords

  • Adipose Tissue
  • Biomechanics
  • Infrapatellar fat pad
  • MRI
  • Osteoarthritis
  • Suprapatellar fat pad
  • knee

Cite this

Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis. / FontanellaThese Authors Equally Contributed To The, Chiara Giulia; Belluzzi, Elisa; Rossato, Marco; Olivotto, Eleonora; Trisolino, Giovanni; Ruggieri, Pietro; Rubini, Alessandro; Porzionato, Andrea; Natali, Arturo; De Caro, Raffaele; Vettor, Roberto; Ramonda, Roberta; Macchi, Veronica; Favero, Marta.

In: Annals of Anatomy, Vol. 221, 10.2018, p. 108-114.

Research output: Contribution to journalArticle

FontanellaThese Authors Equally Contributed To The, CG, Belluzzi, E, Rossato, M, Olivotto, E, Trisolino, G, Ruggieri, P, Rubini, A, Porzionato, A, Natali, A, De Caro, R, Vettor, R, Ramonda, R, Macchi, V & Favero, M 2018, 'Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis.', Annals of Anatomy, vol. 221, pp. 108-114. https://doi.org/10.1016/j.aanat.2018.09.007
FontanellaThese Authors Equally Contributed To The, Chiara Giulia ; Belluzzi, Elisa ; Rossato, Marco ; Olivotto, Eleonora ; Trisolino, Giovanni ; Ruggieri, Pietro ; Rubini, Alessandro ; Porzionato, Andrea ; Natali, Arturo ; De Caro, Raffaele ; Vettor, Roberto ; Ramonda, Roberta ; Macchi, Veronica ; Favero, Marta. / Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis. In: Annals of Anatomy. 2018 ; Vol. 221. pp. 108-114.
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title = "Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis.",
abstract = "The aim of this study was to analyze the magnetic resonance imaging (MRI) volumetric and morphometric characteristics of the infrapatellar fat pad (IFP) and the suprapatellar fat pad (SFP) in normal controls, moderate and end-stage osteoarthritis (OA) patients. Forty-four MRI images of the three groups were collected: a) 17 patients undergoing meniscectomy with Outerbridge score 0 (control group); b) 15 patients undergoing meniscectomy with Outerbridge score 3/4 (moderate OA group); and c) 12 patients undergoing total knee replacement (end-stage OA group). Volume, depth, femoral and tibial arch lengths of IFP were quantified. The hypointense IFP signals were also scored. The SFP volume, oblique, antero-posterior and, cranio-caudal lengths were determined. IFP and SFP characteristics were compared between groups. A decrease of IFP volume, depth, femoral, and tibial arch lengths in moderate and end-stage OA compared to controls were observed. A difference in IFP hypointense signal was found between groups. No differences were found in SFP characteristics between the groups. In controls and moderate OA patients, correlations were found among the different MRI characteristics of both IFP and SFP, while in the end-stage OA group correlations were found only in SFP. We evidenced differences of the IFP MRI morphometric characteristics between the groups analyzed, supporting an important role of IFP in OA pathology and progression. On the contrary, no differences were highlighted in SFP analysis suggesting that this fat pad is not clearly involved in OA, probably due to its peculiar localization and different function.",
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T1 - Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis.

AU - FontanellaThese Authors Equally Contributed To The, Chiara Giulia

AU - Belluzzi, Elisa

AU - Rossato, Marco

AU - Olivotto, Eleonora

AU - Trisolino, Giovanni

AU - Ruggieri, Pietro

AU - Rubini, Alessandro

AU - Porzionato, Andrea

AU - Natali, Arturo

AU - De Caro, Raffaele

AU - Vettor, Roberto

AU - Ramonda, Roberta

AU - Macchi, Veronica

AU - Favero, Marta

N1 - Copyright © 2018. Published by Elsevier GmbH.

PY - 2018/10

Y1 - 2018/10

N2 - The aim of this study was to analyze the magnetic resonance imaging (MRI) volumetric and morphometric characteristics of the infrapatellar fat pad (IFP) and the suprapatellar fat pad (SFP) in normal controls, moderate and end-stage osteoarthritis (OA) patients. Forty-four MRI images of the three groups were collected: a) 17 patients undergoing meniscectomy with Outerbridge score 0 (control group); b) 15 patients undergoing meniscectomy with Outerbridge score 3/4 (moderate OA group); and c) 12 patients undergoing total knee replacement (end-stage OA group). Volume, depth, femoral and tibial arch lengths of IFP were quantified. The hypointense IFP signals were also scored. The SFP volume, oblique, antero-posterior and, cranio-caudal lengths were determined. IFP and SFP characteristics were compared between groups. A decrease of IFP volume, depth, femoral, and tibial arch lengths in moderate and end-stage OA compared to controls were observed. A difference in IFP hypointense signal was found between groups. No differences were found in SFP characteristics between the groups. In controls and moderate OA patients, correlations were found among the different MRI characteristics of both IFP and SFP, while in the end-stage OA group correlations were found only in SFP. We evidenced differences of the IFP MRI morphometric characteristics between the groups analyzed, supporting an important role of IFP in OA pathology and progression. On the contrary, no differences were highlighted in SFP analysis suggesting that this fat pad is not clearly involved in OA, probably due to its peculiar localization and different function.

AB - The aim of this study was to analyze the magnetic resonance imaging (MRI) volumetric and morphometric characteristics of the infrapatellar fat pad (IFP) and the suprapatellar fat pad (SFP) in normal controls, moderate and end-stage osteoarthritis (OA) patients. Forty-four MRI images of the three groups were collected: a) 17 patients undergoing meniscectomy with Outerbridge score 0 (control group); b) 15 patients undergoing meniscectomy with Outerbridge score 3/4 (moderate OA group); and c) 12 patients undergoing total knee replacement (end-stage OA group). Volume, depth, femoral and tibial arch lengths of IFP were quantified. The hypointense IFP signals were also scored. The SFP volume, oblique, antero-posterior and, cranio-caudal lengths were determined. IFP and SFP characteristics were compared between groups. A decrease of IFP volume, depth, femoral, and tibial arch lengths in moderate and end-stage OA compared to controls were observed. A difference in IFP hypointense signal was found between groups. No differences were found in SFP characteristics between the groups. In controls and moderate OA patients, correlations were found among the different MRI characteristics of both IFP and SFP, while in the end-stage OA group correlations were found only in SFP. We evidenced differences of the IFP MRI morphometric characteristics between the groups analyzed, supporting an important role of IFP in OA pathology and progression. On the contrary, no differences were highlighted in SFP analysis suggesting that this fat pad is not clearly involved in OA, probably due to its peculiar localization and different function.

KW - Adipose Tissue

KW - Biomechanics

KW - Infrapatellar fat pad

KW - MRI

KW - Osteoarthritis

KW - Suprapatellar fat pad

KW - knee

U2 - 10.1016/j.aanat.2018.09.007

DO - 10.1016/j.aanat.2018.09.007

M3 - Article

C2 - 30292837

VL - 221

SP - 108

EP - 114

JO - Annals of Anatomy

JF - Annals of Anatomy

SN - 0940-9602

ER -