Quantitative proteomics as a new piece of the systems biology puzzle

Angela Bachi, Tiziana Bonaldi

Research output: Contribution to journalArticle

Abstract

The definition of the role of each gene product in its cellular context is of outstanding importance in the post-genomics era. Recent technological innovations have driven research in proteomics from single protein characterization to global approaches, aiming to achieve a comprehensive qualitative and quantitative description of complex molecular mechanisms. In this review, we discuss the methodology of quantitative proteomics as it applies to the analysis of complex biological model systems. A special attention will be given to model systems that are suitable for functional genomic studies, where the potential of quantitative proteomics can be effectively demonstrated.

Original languageEnglish
Pages (from-to)357-367
Number of pages11
JournalJournal of Proteomics
Volume71
Issue number3
DOIs
Publication statusPublished - Aug 21 2008

Keywords

  • Gene-phenotypization
  • Mass spectrometry
  • Quantitative proteomics
  • Stable-isotope labeling
  • System biology

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

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