Quantitative relationship between coronary artery calcium and myocardial blood flow by hybrid rubidium-82 PET/CT imaging in patients with suspected coronary artery disease

Roberta Assante, Emilia Zampella, Parthiban Arumugam, Wanda Acampa, Massimo Imbriaco, Deborah Tout, Mario Petretta, Christine Tonge, Alberto Cuocolo

Research output: Contribution to journalArticle

Abstract

Background: We assessed the relationship between coronary artery calcium (CAC) score, myocardial blood flow (MBF) and coronary flow reserve (CFR) in patients undergoing hybrid 82Rb positron emission tomography (PET)/computed tomography (CT) imaging for suspected CAD. We also evaluated if CAC score is able to predict a reduced CFR independently from conventional coronary risk factors. Methods: A total of 637 (mean age 58 ± 13 years) consecutive patients were studied. CAC score was measured according to the Agatston method and patients were categorized into 4 groups (0, 0.01-99.9, 100-399.9, and ≥400). Baseline and hyperemic MBF were automatically quantified. CFR was calculated as the ratio of hyperemic to baseline MBF and it was considered reduced when

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Nuclear Cardiology
DOIs
Publication statusAccepted/In press - Jan 15 2016

Keywords

  • Coronary artery calcium
  • coronary artery disease
  • coronary flow reserve
  • myocardial blood flow
  • PET/CT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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