Quantitative scoring of muscle involvement in MRI of neuromuscular diseases

M. E. Fantacci, G. Astrea, R. Battini, A. Retico, C. Sottocornola, M. Tosetti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An automated method to evaluate the fat infiltration in tissues has been developed and applied to images of the human leg. The final aim is to obtain a quantitative evaluation of fat infiltration percentage and to relate it to the grade of muscle impairment in subjects affected by Neuro-Muscular Diseases (NMD). Through a muscle segmentation algorithm on structural T1-weighted magnetic resonance images (MRIs), the estimated non-muscle percentage (eNMP) in the segmented muscle area has been evaluated in healthy subjects as a reference value. A semi-automated procedure allows extending the algorithm to MRIs of NMD patients. A strong correlation has been demonstrated between the eNMP index and the disease severity.

Original languageEnglish
Title of host publicationBIOIMAGING 2015 - 2nd International Conference on Bioimaging, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015
PublisherSciTePress
Pages100-105
Number of pages6
ISBN (Print)9789897580727
Publication statusPublished - 2015
Event2nd International Conference on Bioimaging, BIOIMAGING 2015 - Lisbon, Portugal
Duration: Jan 12 2015Jan 15 2015

Other

Other2nd International Conference on Bioimaging, BIOIMAGING 2015
CountryPortugal
CityLisbon
Period1/12/151/15/15

Keywords

  • Muscle MRI
  • Muscle segmentation
  • Neuromuscular diseases

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Fantacci, M. E., Astrea, G., Battini, R., Retico, A., Sottocornola, C., & Tosetti, M. (2015). Quantitative scoring of muscle involvement in MRI of neuromuscular diseases. In BIOIMAGING 2015 - 2nd International Conference on Bioimaging, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015 (pp. 100-105). SciTePress.