Quantitative scoring of muscle involvement in MRI of neuromuscular diseases

M. E. Fantacci, G. Astrea, R. Battini, A. Retico, C. Sottocornola, M. Tosetti

Research output: Chapter in Book/Report/Conference proceedingConference contribution


An automated method to evaluate the fat infiltration in tissues has been developed and applied to images of the human leg. The final aim is to obtain a quantitative evaluation of fat infiltration percentage and to relate it to the grade of muscle impairment in subjects affected by Neuro-Muscular Diseases (NMD). Through a muscle segmentation algorithm on structural T1-weighted magnetic resonance images (MRIs), the estimated non-muscle percentage (eNMP) in the segmented muscle area has been evaluated in healthy subjects as a reference value. A semi-automated procedure allows extending the algorithm to MRIs of NMD patients. A strong correlation has been demonstrated between the eNMP index and the disease severity.

Original languageEnglish
Title of host publicationBIOIMAGING 2015 - 2nd International Conference on Bioimaging, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015
Number of pages6
ISBN (Print)9789897580727
Publication statusPublished - 2015
Event2nd International Conference on Bioimaging, BIOIMAGING 2015 - Lisbon, Portugal
Duration: Jan 12 2015Jan 15 2015


Other2nd International Conference on Bioimaging, BIOIMAGING 2015


  • Muscle MRI
  • Muscle segmentation
  • Neuromuscular diseases

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Quantitative scoring of muscle involvement in MRI of neuromuscular diseases'. Together they form a unique fingerprint.

Cite this