Quantitative study of ductal breast cancer progression. A progression index (P.I.) for premalignant lesions and in situ carcinoma

Gian Mario Mariuzzi, L. Mariuzzi, A. Mombello, A. Santinelli, M. Valli, D. Rahal, D. Thompson, P. H. Bartels

Research output: Contribution to journalArticlepeer-review

Abstract

The diagnostic subjective assessment of ductal premalignant proliferative lesions and in situ carcinoma of the breast produces unsatisfactory results. Since the phenotypical cell changes in tumour progression toward infiltrating cancer constitute a continuum, a grading on a continuous scale of values produces a more reliable and reproducible characterization. The diagnostic assessment for any individual patient may be expressed by a progression index (P.I.): its numerical values are based on the cellular changes measured in the individual cases. In this study, the progression index is based an two morphometric features, nuclear size and nucleolar area. In addition, the method presented may produce a ratio, stating the relative likelihood that each case represents one of the conventional diagnostic categories. Such a likelihood ratio may be obtained from the bivariate distribution of nuclear size and nucleolar area for the conventional diagnostic categories.

Original languageEnglish
Pages (from-to)428-436
Number of pages9
JournalPathology Research and Practice
Volume192
Issue number5
Publication statusPublished - 1996

Keywords

  • Atypical epitheliosis
  • Breast
  • C-erb-B2
  • Ductal cancer
  • Ductal carcinoma in situ (DCIS)
  • Epitheliosis
  • Grading
  • Prognosis
  • Progression index (P.I.)
  • Quantitative pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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