TY - JOUR
T1 - Quantitative study of ductal breast cancer progression. A progression index (P.I.) for premalignant lesions and in situ carcinoma
AU - Mariuzzi, Gian Mario
AU - Mariuzzi, L.
AU - Mombello, A.
AU - Santinelli, A.
AU - Valli, M.
AU - Rahal, D.
AU - Thompson, D.
AU - Bartels, P. H.
PY - 1996
Y1 - 1996
N2 - The diagnostic subjective assessment of ductal premalignant proliferative lesions and in situ carcinoma of the breast produces unsatisfactory results. Since the phenotypical cell changes in tumour progression toward infiltrating cancer constitute a continuum, a grading on a continuous scale of values produces a more reliable and reproducible characterization. The diagnostic assessment for any individual patient may be expressed by a progression index (P.I.): its numerical values are based on the cellular changes measured in the individual cases. In this study, the progression index is based an two morphometric features, nuclear size and nucleolar area. In addition, the method presented may produce a ratio, stating the relative likelihood that each case represents one of the conventional diagnostic categories. Such a likelihood ratio may be obtained from the bivariate distribution of nuclear size and nucleolar area for the conventional diagnostic categories.
AB - The diagnostic subjective assessment of ductal premalignant proliferative lesions and in situ carcinoma of the breast produces unsatisfactory results. Since the phenotypical cell changes in tumour progression toward infiltrating cancer constitute a continuum, a grading on a continuous scale of values produces a more reliable and reproducible characterization. The diagnostic assessment for any individual patient may be expressed by a progression index (P.I.): its numerical values are based on the cellular changes measured in the individual cases. In this study, the progression index is based an two morphometric features, nuclear size and nucleolar area. In addition, the method presented may produce a ratio, stating the relative likelihood that each case represents one of the conventional diagnostic categories. Such a likelihood ratio may be obtained from the bivariate distribution of nuclear size and nucleolar area for the conventional diagnostic categories.
KW - Atypical epitheliosis
KW - Breast
KW - C-erb-B2
KW - Ductal cancer
KW - Ductal carcinoma in situ (DCIS)
KW - Epitheliosis
KW - Grading
KW - Prognosis
KW - Progression index (P.I.)
KW - Quantitative pathology
UR - http://www.scopus.com/inward/record.url?scp=0030016267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030016267&partnerID=8YFLogxK
M3 - Article
C2 - 8832747
AN - SCOPUS:0030016267
VL - 192
SP - 428
EP - 436
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
IS - 5
ER -