Quantitative Ultrasond in the assessment of Osteoporosis

Giuseppe Guglielmi, Francesca de Terlizzi

Research output: Contribution to journalArticlepeer-review


Quantitative ultrasound (QUS) is used in the clinical setting to identify changes in bone tissue connected with menopause, osteoporosis and bone fragility. The versatility of the technique, its low cost and lack of ionizing radiation have led to the use of this method worldwide. Furthermore, with increased clinical interest among clinicians, QUS has been applied to several field of investigation of bone, in various pathologies of bone metabolism, in paediatrics, neonatology, genetics and other fields. Several studies have been carried out in recent years to investigate the potential of QUS, with important positive results. The technique is able to predict osteoporotic fractures; some evidence of the ability to monitor therapies has been reported; the usefulness in the management of secondary osteoporosis has been confirmed; studies in paediatrics have reported reference curves for some QUS devices, and there have been relevant studies in conditions involving metabolic bone disorders. This article is an overview of the most relevant developments in the field of QUS, both in the clinical and in the experimental settings. The advantages and limitations of the present technique have been outlined, together with suggestions for the use in the clinical practice. Crown

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalEuropean Journal of Radiology
Issue number3
Publication statusPublished - Sep 2009


  • Amplitude dependent speed of sound (AD-SoS)
  • Bone quality
  • Broadband ultrasound attenuation (BUA)
  • Osteoporosis
  • Quantitative ultrasound (QUS)
  • Quantitative ultrasound index (QUI)
  • Speed of sound (SoS)
  • Stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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